Evidence map›Paper›PMID 28074470›Full record

ArticleFEBS letters2017

Evidence that oxidative dephosphorylation by the nonheme Fe(II), α-ketoglutarate:UMP oxygenase occurs by stereospecific hydroxylation.

Anwesha Goswami, Xiaodong Liu, Wenlong Cai, Thomas P Wyche, Tim S Bugni, Maïa Meurillon, Suzanne Peyrottes, Christian Perigaud, Koichi Nonaka, Jürgen Rohr and 1 more

Open access · bronzeAbstract readLetter
In one paragraph

Article in FEBS letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Biosynthesis and Genome Mining Potentials of Nucleoside Natural Products.Chembiochem : a European journal of chemical biology · 2023
    Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Pyridoxal-5'-phosphate as an oxygenase cofactor: Discovery of a carboxamide-forming, α-amino acid monooxygenase-decarboxylase.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Anwesha GoswamiDepartment of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, USA.
Xiaodong LiuDepartment of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, USA.
Wenlong CaiDepartment of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, USA.
Thomas P WycheDepartment of Pharmaceutical Sciences, University of Wisconsin-Madison, WI, USA.
Tim S BugniDepartment of Pharmaceutical Sciences, University of Wisconsin-Madison, WI, USA.
Maïa MeurillonNucleosides and Phosphorylated Effectors Team, IBMM, UMR5247 CNRS University Montpellier, France.
Suzanne PeyrottesNucleosides and Phosphorylated Effectors Team, IBMM, UMR5247 CNRS University Montpellier, France.
Christian PerigaudNucleosides and Phosphorylated Effectors Team, IBMM, UMR5247 CNRS University Montpellier, France.
Koichi NonakaBiologics Technology Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., Gunma, Japan.
Jürgen RohrDepartment of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, USA.
Steven G Van LanenDepartment of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, USA.
University of Kentucky · USCentre National de la Recherche Scientifique · FRUniversity of Wisconsin–Madison · USDaiichi-Sankyo (Japan) · JPInstitut des Biomolécules Max Mousseron · FR

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
NOVEL AUREOLIC ACID TYPE ANTITUMOR AGENTSR01CA091901 · NCI · UNIVERSITY OF KENTUCKY · PI ROHR, JURGEN T · 2001 to 2017
$3.6M
Biosynthesis of nucleoside antibiotics targeting bacterial translocase IR01AI087849 · NIAID · UNIVERSITY OF KENTUCKY · PI VAN LANEN, STEVEN GARY · 2011 to 2020
$3.3M
Exploring Post-Type II PKS Frame ModificationsR01GM105977 · NIGMS · UNIVERSITY OF KENTUCKY · PI ROHR, JURGEN T · 2014 to 2017
$1.1M
Biosynthesis and medicinal chemistry of the capuramycin antimycobacterial antibioticsR01AI128862 · NIAID · UNIVERSITY OF KENTUCKY · PI THORSON, JON SCOTT, VAN LANEN, STEVEN GARY · 2017 to 2021
$1.0M
NCATS NIH HHS UL1 TR000117NCI NIH HHS R01 CA091901NIAID NIH HHS R01 AI087849NIAID NIH HHS R01 AI128862NIGMS NIH HHS R01 GM105977
6 · The paper itself

Abstract

LipL and Cpr19 are nonheme, mononuclear Fe(II)-dependent, α-ketoglutarate (αKG):UMP oxygenases that catalyze the formation of CO

Indexed as

BiocatalysisHemeHydrogenHydroxylationIronKetoglutaric AcidsOxidation-ReductionOxygenasesPhosphorylationStereoisomerismSubstrate SpecificityUridine MonophosphateHemeHydrogenIronKetoglutaric AcidsOxygenasesUridine Monophosphateantibioticbiosynthesisnonheme ironnucleosideoxygenasetranslocase I

Identifiers

PMID28074470
PMCPMC5380139
OpenAlexW2576708381

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.