Stereo- and region-specific biotransformation of physapubescin by four fungal strains.

Chongyue Qiu, Ting Yuan, Dejuan Sun, Suyu Gao, Lixia Chen

Abstract read

In one paragraph

Article in Journal of natural medicines, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Chongyue QiuKey Laboratory of Structure-Based Drug Design & Discovery, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Wuya College of Innovation, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.

Ting YuanKey Laboratory of Structure-Based Drug Design & Discovery, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Wuya College of Innovation, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.

Dejuan SunKey Laboratory of Structure-Based Drug Design & Discovery, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Wuya College of Innovation, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.

Suyu GaoKey Laboratory of Structure-Based Drug Design & Discovery, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Wuya College of Innovation, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.

Lixia ChenKey Laboratory of Structure-Based Drug Design & Discovery, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Wuya College of Innovation, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China. syzyclx@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biotransformations of physapubescin (1) were performed by four fungal strains-Mucor subtilissimus AS 3.2454, Mucor polymorphosporus AS 3.3443, Aspergillus niger AS 3.795, and Syncephalastrum racemosum AS 3.264. Four metabolites were prepared in the biotransformation process of 1, and their structures were elucidated as 15α-acetoxy-5,6β:22,26:24,25-triepoxy-26α-hydroxy-3β-methoxy 4β-hydroxyergost-1-one (2), 15α-acetoxy-5,6β:22,26-diepoxy-4β,24β,25α,26(α, β)-tetrahydroxyergost-3β-methoxy-1-one (3a/3b), 15α-acetoxy-5,6β:22,26-diepoxy-4β,24β,25α,26(α, β)-tetrahydroxyergost-2-en-1-one (4a/4b), and physapubescin D (5), by spectroscopic data analysis. Among them, metabolites 2 and 3 are new. All of these fungal strains showed the ability to be highly stereo- and region-specific for the bioconversion of substrate (1). Our research provides a reference for the structural derivatization of withanolides or possibly even other natural products.

Indexed as

BiotransformationFungiMolecular StructureWithanolidesphysapubescinWithanolidesBiotransformationFungal strainsPhysapubescin

Identifiers

PMID28074432

DOI10.1007/s11418-016-1068-z

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