ReviewThe international journal of cardiovascular imaging2017
High wall shear stress and high-risk plaque: an emerging concept.
Review in The international journal of cardiovascular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05907629 (Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging), which is not on this map. Cited by 78 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging
Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 155 citations in OpenAlex.
- Effects of Ageing on Aortic Circulation During Atrial Fibrillation; a Numerical Study on Different Aortic Morphologies.Annals of biomedical engineering · 2021Pooled it
- Preclinical techniques to investigate exercise training in vascular pathophysiology.American journal of physiology. Heart and circulatory physiology · 2021Pooled it
- An MRI-based method to register patient-specific wall shear stress data to histology.PloS one · 2019Trial
- Clinical OCT computation-modeled prognosis of coronary plaque progression with validation by fusogenic macrophage nano-targeting.Nano convergence · 2026Article
- Atherosclerotic middle cerebral artery stenosis: adjacent arterial geometry, hemodynamics and plaque features.Japanese journal of radiology · 2026Article
- Multimodal Risk Stratification Clue of Carotid Bifurcation Plaques: A Cross-Sectional Observational Study of Vector Flow Imaging, Plaque-RADS, and Clinical Factors.Translational stroke research · 2026Observational
- Intravascular ultrasound wall shear stress imaging in stented coronary arteries with ultrafast Doppler.Scientific reports · 2026Article
- A One-Dimensional (1D) Computational Fluid Dynamics Study of Fontan-Associated Liver Disease (FALD).International journal for numerical methods in biomedical engineering · 2026Article
- Application of multimodal ultrasound in the biomechanical evaluation of carotid intima-media thickness in type 2 diabetes mellitus: a focus on subclinical vascular changes.Frontiers in endocrinology · 2026Article
- Biomechanics of Plaque Rupture and Cardiovascular Calcification.Advances in experimental medicine and biology · 2026Review
- Newly Proposed Method With Noise-Reduction and Smoothing for Computational Fluid Dynamics Using Low-Resolution Medical Images.International journal for numerical methods in biomedical engineering · 2025Article
- Device-Oriented CFD Comparison of Rectangular and Circular Microchannels with Single and Double Asymmetric Stenoses Under Identical Operating Conditions.Bioengineering (Basel, Switzerland) · 2025Article
- Endovascular structures of the basilar artery as forms of the basilar nonfusion spectrum.Scientific reports · 2025Article
- High-intensity helical flow: a double-edged sword in coronary artery haemodynamics.Royal Society open science · 2025Article
- High Wall Shear Stress Is Related to Complicated American Heart Association Lesion Type VI Plaques in Mild-to-Moderate ICA Stenosis: A 3D Cardiovascular MRI Study.AJNR. American journal of neuroradiology · 2025Article
- Endothelial Function and Pro-Inflammatory Cytokines as Prognostic Markers in Acute Coronary Syndromes.Diagnostics (Basel, Switzerland) · 2025Article
- Biophysical and Biochemical Roles of Shear Stress on Endothelium: A Revisit and New Insights.Circulation research · 2025Review
- The Role of 4D Flow MRI-derived Wall Shear Stress in Aortic Disease: A Comprehensive Review.Reviews in cardiovascular medicine · 2025Review
- Hemodynamic effects of stenosis with varying severity in different segments of the carotid artery using computational fluid dynamics.Scientific reports · 2025Article
- The effects of carotid plaque classification and bifurcation angle on plaque: a computational fluid dynamics simulation.Frontiers in physiology · 2025Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
In recent years, there has been a significant effort to identify high-risk plaques in vivo prior to acute events. While number of imaging modalities have been developed to identify morphologic characteristics of high-risk plaques, prospective natural-history observational studies suggest that vulnerability is not solely dependent on plaque morphology and likely involves additional contributing mechanisms. High wall shear stress (WSS) has recently been proposed as one possible causative factor, promoting the development of high-risk plaques. High WSS has been shown to induce specific changes in endothelial cell behavior, exacerbating inflammation and stimulating progression of the atherosclerotic lipid core. In line with experimental and autopsy studies, several human studies have shown associations between high WSS and known morphological features of high-risk plaques. However, despite increasing evidence, there is still no longitudinal data linking high WSS to clinical events. As the interplay between atherosclerotic plaque, artery, and WSS is highly dynamic, large natural history studies of atherosclerosis that include WSS measurements are now warranted. This review will summarize the available clinical evidence on high WSS as a possible etiological mechanism underlying high-risk plaque development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.