Evidence map›Paper›PMID 28074410›Full record

ReviewDrugs & aging2017

Improving Medication Adherence and Health Outcomes in Older Adults: An Evidence-Based Review of Randomized Controlled Trials.

Zachary A Marcum, Joseph T Hanlon, Michael D Murray

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Drugs & aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 4 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Zachary A MarcumSchool of Pharmacy, University of Washington, Seattle, WA, USA.
Joseph T HanlonSchools of Medicine (Geriatrics), Pharmacy, and Public Health, University of Pittsburgh, 3471 Fifth Avenue, Suite #500, Pittsburgh, PA, 15213, USA. jth14@pitt.edu.
Michael D MurrayPurdue University College of Pharmacy and Regenstrief Institute, Indianapolis, IN, USA.
Indiana University – Purdue University Indianapolis · USSeattle University · USUniversity of Pittsburgh · US

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
Pitt Integrated Clinical and Geroscience Research Training ProgramT32AG021885 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Aditi U Gurkar · 2003 to 2026
$6.7M
UW Patient-Centered Outcomes Research Career Development Program K12 2014 2019K12HS022982 · AHRQ · UNIVERSITY OF WASHINGTON · PI SULLIVAN, SEAN D · 2014 to 2018
$3.8M
Improving Outcomes of UTI in LTC Facilities: The IOU StudyR18HS023779 · AHRQ · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NACE, DAVID A. · 2015 to 2017
$1.4M
Integration of Geriatrics Principles into the Care of Older Adults with CardiovasU13AG047008 · NIA · AMERICAN COLLEGE OF CARDIOLOGY · PI RICH, MICHAEL W · 2014 to 2018
$210k
AHRQ HHS K12 HS022982AHRQ HHS R18 HS023779NIA NIH HHS P30 AG024827NIA NIH HHS T32 AG021885NIA NIH HHS U13 AG047008
6 · The paper itself

Abstract

backgroundPoor medication adherence is a major public health problem in older adults often resulting in negative health outcomes.

objectiveThe objective of this review was to provide an updated summary of evidence from randomized controlled studies to determine whether interventions aimed at improving medication adherence also improve the health outcomes of older adults residing in community-based settings.

methodsArticles that assessed medication adherence interventions and related health outcomes in elderly individuals were identified through searches of MEDLINE (1970-June 2016), the Cochrane Database of Systematic Reviews (through to June 2016), and Google Scholar. Across the 12 included studies, interventions were grouped into three main categories: behavioral/educational (n = 3), pharmacist-led (n = 7), and reminder/simplification (n = 2).

resultsAmong the behavioral/educational intervention studies, two showed improvements in both adherence and related health outcomes, whereas one found no changes in adherence or health outcomes. Among the pharmacist-led studies, three showed improvements in both adherence and related health outcomes, while three reported no changes in adherence or health outcomes. One found an improvement in adherence but not health outcomes. Among the reminder/simplification studies, both studies reported improvements in adherence without a significant impact on related health outcomes.

conclusionThis evidence-based review of medication adherence interventions in older adults revealed promising strategies in the larger context of a largely mixed body of literature. Future patient-centered and multidisciplinary interventions should be developed and tested using evidence-based principles to improve medication adherence and health outcomes in older adults.

Indexed as

Medication AdherenceAgedHumansPatient Education as TopicPharmacistsRandomized Controlled Trials as Topic

Identifiers

PMID28074410
PMCPMC5325769
OpenAlexW2569900198

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.