ArticleJournal of neuro-oncology2017
How to deal with giant pituitary adenomas: transsphenoidal or transcranial, simultaneous or two-staged?
Article in Journal of neuro-oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Surgically treated giant pituitary neuroendocrine tumors: systematic review and meta-analysis with institutional cohort.Neurosurgical review · 2026Pooled it
- Simultaneous combined endonasal and transcranial surgery for large skull base tumors invading multiple regions: combination variations, pros and cons, and surgical results.Neurosurgical review · 2026Article
- Giant pituitary adenomas: an institutional experience with 289 surgically treated patients.Acta neurochirurgica · 2026Article
- Combined Endoscopic and Open Cranial Approach for Treatment of Skull Base Lesions: A Case Series and Lessons Learned.Journal of neurological surgery. Part B, Skull base · 2026Article
- Giant and irregular pituitary neuroendocrine tumors surgery: comparison of simultaneous combined endoscopic endonasal and transcranial and purely endoscopic endonasal surgery at a single center.Chinese neurosurgical journal · 2025Article
- Endoscope-assisted transcranial surgery for complex pituitary adenoma: a retrospective case series study with propensity score matching.Neurosurgical review · 2025Article
- Different types of combined endoscopic and transcranial approaches for complex giant pituitary adenomas: how I do it.Acta neurochirurgica · 2024Article
- Neuronavigation-assisted pituitary neuroendocrine tumor resection: a systematic review and meta-analysis.Quantitative imaging in medicine and surgery · 2024Article
- Giant Clinically Non-Functioning Pituitary Adenoma Presenting as New Onset Generalized Tonic‒Clonic Seizures: A Case Report.International medical case reports journal · 2024Article
- A case of acute hydrocephalus due to a giant prolactinoma rescued by transventricular neuroendoscopic tumorectomy.Surgical neurology international · 2023Article
- Endoscopic transcranial transdiaphragmatic approach in a single-stage surgery for giant pituitary adenomas.Frontiers in oncology · 2023Article
- Pituitary adenoma with cavernous sinus compartment penetration and intracranial extension: surgical anatomy, approach, and outcomes.Frontiers in oncology · 2023Article
- Surgical management of giant pituitary adenomas: institutional experience and clinical outcomes of 94 patients.Frontiers in oncology · 2023Article
- Giant Non-Functioning Pituitary Adenomas: Treatment Considerations.Brain sciences · 2022Article
- Estimating Risk of Pituitary Apoplexy after Resection of Giant Pituitary Adenomas.Journal of neurological surgery. Part B, Skull base · 2022Article
- Comparative analysis of pituitary adenoma with and without apoplexy in pediatric and adolescent patients: a clinical series of 80 patients.Neurosurgical review · 2022Article
- Relationship with the diaphragm to predict the surgical outcome in large and giant pituitary adenomas.Frontiers in surgery · 2022Article
- Surgical management of giant pituitary neuroendocrine tumors: Meta-analysis and consensus statement on behalf of the EANS skull base section.Brain & spine · 2022Article
- Microscopic Transsphenoidal Resection of Giant Pituitary Adenomas: Analysis of the Factors Limiting the Degree of Resection in 73 Cases.Frontiers in neurology · 2022Article
- Transcranial approach as surgical treatment for giant pituitary adenoma during COVID 19 pandemic - What can we learn?: A case report.Interdisciplinary neurosurgery : Advanced techniques and case management · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Giant pituitary adenomas (diameter >4 cm) are a challenge to treat, and there is no consensus on the optimal surgical strategy. We report here our experience in surgical management of these lesions. Adult patients with giant pituitary adenomas (n = 62; 54 non-functioning and eight hormone-secreting adenomas) who underwent surgical resection at our hospital from 2009 to 2015 were retrospectively reviewed. Surgical and clinical outcomes were analyzed. Single transsphenoidal and transcranial approaches were used in 43 (69.4%) and four (6.5%) patients, respectively. A combined transsphenoidal and transcranial approach was used in 13 patients (20.9%) and in two patients (3.2%), a transcranial procedure was followed 3 months later by a transsphenoidal approach. Greater than 90% resection was achieved in 47 cases (75.8%). During a mean follow-up period of 46.9 months, 49 patients (79%) showed improved visual impairment scores, while none experienced visual deterioration. There was no post-operative hemorrhage or mortality. A total of 27 patients (43.5%) received adjuvant medical and/or radiation therapy. At last follow-up, eight patients (12.9%) had recurrence. For giant pituitary adenoma, the transsphenoidal and transcranial approaches should be combined flexibly based on the characteristics of the tumor. In certain cases, a simultaneous combined approach can maximize tumor extirpation and lower the risk of swelling and bleeding of the residual tumor.
Indexed as
Identifiers
28074324What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.