Evidence map›Paper›PMID 28074087›Full record

ArticleThrombosis journal2017

The genetic variation rs6903956 in the novel androgen-dependent tissue factor pathway inhibitor regulating protein (

Xuling Chang, Hui-Lin Chin, Swee-Chye Quek, Daniel Y T Goh, Rajkumar Dorajoo, Yechiel Friedlander, Chew-Kiat Heng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thrombosis journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Xuling ChangDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore, 119228 Singapore ; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore.
Hui-Lin ChinDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore, 119228 Singapore ; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore.
Swee-Chye QuekDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore, 119228 Singapore ; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore.
Daniel Y T GohDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore, 119228 Singapore ; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore.
Rajkumar DorajooGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Yechiel FriedlanderSchool of Public Health and Community Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Chew-Kiat HengDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore, 119228 Singapore ; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore.ORCID 0000-0002-7309-9473
National University of Singapore · SGAgency for Science, Technology and Research · SGHebrew University of Jerusalem · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenome-wide association study (GWAS) has reported that rs6903956 within the first intron of androgen-dependent tissue factor pathway inhibitor (TFPI) regulating protein (

methodsWe conducted the analysis in both Chinese adult (

resultsNo significant association was observed between rs6903956 and plasma FVIIc nor fibrinogen levels with adjustment for age, gender, body mass index (BMI) and cigarette smoking in adults (P for FVIIc = 0.464; P for fibrinogen = 0.349). The SNP was also not associated with these two coagulation factors in the neonates (P for FVIIc = 0.579; P for fibrinogen = 0.359) after adjusting for gestational age, gender and birth weight.

conclusionsSNP rs6903956 on

Indexed as

Androgen-dependent tissue factor pathway inhibitor regulating proteinCoagulation factorsCoronary artery diseaseGenetic variant

Identifiers

PMID28074087
PMCPMC5219704
OpenAlexW2570581588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.