Evidence map›Paper›PMID 28074055›Full record

ArticleThe Journal of antibiotics2017

Effects of two 6-quinolinyl chalcones on the integrity of plasma membrane of Paracoccidioides brasiliensis.

Nívea P de Sá, Patrícia S Cisalpino, Luciana C Tavares, Leandro Espíndola, Beatriz M Borelli, Paulo Js Barbeira, Gabriele de Matos Cardoso Perdigão, Elaine M Souza-Fagundes, Carlos A Rosa, Moacir G Pizzolatti and 1 more

Open access · bronzeAbstract read
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In one paragraph

Article in The Journal of antibiotics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Nívea P de SáDepartamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil.
Patrícia S CisalpinoDepartamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil.
Luciana C TavaresDepartamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
Leandro EspíndolaDepartamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
Beatriz M BorelliDepartamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil.
Paulo Js BarbeiraDepartamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, MG, Brazil.
Gabriele de Matos Cardoso PerdigãoDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil.
Elaine M Souza-FagundesDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil.
Carlos A RosaDepartamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil.
Moacir G PizzolattiDepartamento de Química, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
Susana JohannDepartamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil.
Universidade Federal de Minas Gerais · BRUniversidade Federal de Santa Catarina · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paracoccidioidomycosis is the most prevalent systemic mycosis in Latin America, yet few therapeutic options exist. Our aim was to search for new compounds with high efficacy, low toxicity, shorter treatment time and affordable cost. We studied two synthetic 6-quinolinyl chalcones, 3b and 3e, to determine their effects on VERO cells, antifungal activity, survival curve, interaction with other drugs and phenotypic effects against several isolates of Paracoccidioides spp. In this study, we verified that the compounds were not toxic, exhibited superior in vitro activity compared with that shown by trimethoprim-sulfamethoxazole, and after 5 days of treatment, decreased the fungal cell viability by approximately 70%. Additionally, no interactions were observed between the tested compounds and other drugs. We also found that these compounds induced morphological changes, such as shriveling of cells, fragmentation of the plasma membrane and cytoplasmic disorganization in vitro. The changes observed by microscopy assays corroborate the observation made with propidium iodide, where the number of cells stained with the compounds was higher than that observed after amphotericin B treatment. We observed an increase in the efflux of K

Indexed as

Amphotericin BAnimalsAntifungal AgentsCell MembraneChalconesChlorocebus aethiopsCytoplasmErgosterolMicrobial Sensitivity TestsParacoccidioidesParacoccidioidomycosisPotassiumTrimethoprim, Sulfamethoxazole Drug CombinationVero CellsAmphotericin BAntifungal AgentsChalconesErgosterolPotassiumTrimethoprim, Sulfamethoxazole Drug Combination

Identifiers

PMID28074055
OpenAlexW2579084172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.