ArticleThe Journal of antibiotics2017
Elmenols C-H, new angucycline derivatives isolated from a culture of Streptomyces sp. IFM 11490.
Article in The Journal of antibiotics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Bioactive Metabolites from Terrestrial and Marine Actinomycetes.Molecules (Basel, Switzerland) · 2023Review
- Antibacterial and Cytotoxic Bridged and Ring Cleavage Angucyclinones From a MarineFrontiers in chemistry · 2020Article
- Heliomycin and tetracinomycin D: anthraquinone derivatives with histone deacetylase inhibitory activity from marine sponge-associated3 Biotech · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Chemical investigations of the ethyl acetate extract of Streptomyces sp. IFM 11490 have led to the isolation of six new angucycline metabolites, named elmenols C-H (1-6), along with the previously reported elmonin (7) and elmenols A (8) and B (9). The known LS1924A (10), 6-deoxy-8-methylrabelomycin (11), tetrangulol methyl ether (12) and angucyclinone (13) were additionally identified. The structures of the isolated compounds were elucidated by means of spectroscopic methods including UV, IR, HRESIMS, and 1D and 2D NMR. Compounds 1-6 were evaluated for their abilities to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance in human gastric adenocarcinoma (AGS) cells. Compounds 5 (10 μm) and 6 (50 μm) in combination with TRAIL showed moderate activity in sensitizing TRAIL-resistant AGS cells.
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Registered trials
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