ArticleProceedings of the National Academy of Sciences of the United States of America2017
Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 49 citations in OpenAlex.
- Cross-Neutralizing and Broadly Neutralizing Human Antibodies Against Nonenveloped Viruses.European journal of immunology · 2026Review
- Molecular, serological, and epidemiological characterisation of a hepatitis A virus outbreak in Maharashtra, India, 2025.The Indian journal of medical research · 2026Article
- Atomic-Level Engineering of Synthetic Receptors for Enhanced Virus Detection and Removal.Advanced healthcare materials · 2025Article
- A single residue switch mediates the broad neutralization of Rotaviruses.Nature communications · 2025Article
- Discovery, recognized antigenic structures, and evolution of cross-serotype broadly neutralizing antibodies from porcine B-cell repertoires against foot-and-mouth disease virus.PLoS pathogens · 2024Article
- A Useful Method to Provide Infectious and Cultivable In Vitro Naked Viral Particles of Hepatitis A Virus.Viruses · 2024Article
- Hepatitis A virus infection.Nature reviews. Disease primers · 2023Review
- Cell entry and release of quasi-enveloped human hepatitis viruses.Nature reviews. Microbiology · 2023Review
- Oligomers of hepatitis A virus (HAV) capsid protein VP1 generated in a heterologous expression system.Microbial cell factories · 2022Article
- Structural basis for neutralization of an anicteric hepatitis associated echovirus by a potent neutralizing antibody.Cell discovery · 2021Article
- Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating.Cell host & microbe · 2021Article
- Mechanisms of Rhinovirus Neutralisation by Antibodies.Viruses · 2021Review
- Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection.Cell research · 2021Article
- Article
- First evidence for continuous circulation of hepatitis A virus subgenotype IIA in Central Africa.Journal of viral hepatitis · 2020Article
- Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody.Science (New York, N.Y.) · 2020Article
- Structures of Echovirus 30 in complex with its receptors inform a rational prediction for enterovirus receptor usage.Nature communications · 2020Article
- Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B.Nature communications · 2020Article
- Gangliosides are essential endosomal receptors for quasi-enveloped and naked hepatitis A virus.Nature microbiology · 2020Article
- Neutralization Mechanism of a Monoclonal Antibody Targeting a Porcine Circovirus Type 2 Cap Protein Conformational Epitope.Journal of virology · 2020Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
Hepatitis A virus (HAV) infects ∼1.4 million people annually and, although there is a vaccine, there are no licensed therapeutic drugs. HAV is unusually stable (making disinfection problematic) and little is known of how it enters cells and releases its RNA. Here we report a potent HAV-specific monoclonal antibody, R10, which neutralizes HAV infection by blocking attachment to the host cell. High-resolution cryo-EM structures of HAV full and empty particles and of the complex of HAV with R10 Fab reveal the atomic details of antibody binding and point to a receptor recognition site at the pentamer interface. These results, together with our observation that the R10 Fab destabilizes the capsid, suggest the use of a receptor mimic mechanism to neutralize virus infection, providing new opportunities for therapeutic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.