ArticleScience signaling2017
Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Science signaling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05603702 (STTEPP), which is not on this map. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT05603702 phase1active not recruitingnot on this mapstarted 2023, after this paper: background citation
STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis
Who cites it
33 citing papers in PubMed, 87 citations in OpenAlex.
- Chasing the Wrong Door for 30 Years: Is Suzetrigine the Key to Selective Pain Relief?Medicina (Kaunas, Lithuania) · 2026Review
- Decoding orofacial pain: a translational review of mechanisms and novel therapies.The journal of headache and pain · 2025Review
- BH4 Oxidation-Derived HJournal of neurochemistry · 2025Article
- Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine).The Journal of general physiology · 2025Review
- Toxoplasma gondii chronic infection decreases visceral nociception through peripheral opioid receptor signaling.PLoS pathogens · 2025Article
- Sustained fentanyl exposure inhibits neuronal activity in dissociated striatal neuronal-glial cocultures through actions independent of opioid receptors.Journal of neurophysiology · 2024Article
- Diversely evolved xibalbin variants from remipede venom inhibit potassium channels and activate PKA-II and Erk1/2 signaling.BMC biology · 2024Article
- Safety, Tolerability, and Dose-Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis: Protocol for a Phase 1 Clinical Trial to Determine Safety and Identify Side Effects.JMIR research protocols · 2024Article
- NaExperimental neurology · 2023Article
- Glycyrrhizic Acid Prevents Paclitaxel-Induced Neuropathy via Inhibition of OATP-Mediated Neuronal Uptake.Cells · 2023Article
- Genetic pain loss disorders.Nature reviews. Disease primers · 2022Review
- Dose-dependent consequences of sub-chronic fentanyl exposure on neuron and glial co-cultures.Frontiers in toxicology · 2022Article
- Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents.Science translational medicine · 2021Article
- Depolarization induces nociceptor sensitization by CaV1.2-mediated PKA-II activation.The Journal of cell biology · 2021Article
- Article
- The physiological function of different voltage-gated sodium channels in pain.Nature reviews. Neuroscience · 2021Review
- Long-lasting analgesia via targeted in situ repression of NaScience translational medicine · 2021Article
- Serotonin enhances depolarizing spontaneous fluctuations, excitability, and ongoing activity in isolated rat DRG neurons via 5-HTNeuropharmacology · 2021Article
- Depolarization-Dependent C-Raf Signaling Promotes Hyperexcitability and Reduces Opioid Sensitivity of Isolated Nociceptors after Spinal Cord Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Complementary roles of murine NaScientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Jörg IsenseeDepartment of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology and Pain Research, University Hospital of Cologne, Robert Koch Str. 10, 50931 Cologne, Germany. joerg.isensee@uk-koeln.de tim.hucho@uk-koeln.de.
Leonhardt KrahéDepartment of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology and Pain Research, University Hospital of Cologne, Robert Koch Str. 10, 50931 Cologne, Germany.
Katharina MoellerDepartment of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology and Pain Research, University Hospital of Cologne, Robert Koch Str. 10, 50931 Cologne, Germany.
Vanessa PereiraMolecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.
Jane E SextonMolecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.
Xiaohui SunMolecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.
Edward EmeryMolecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.
John N WoodMolecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.
Tim HuchoDepartment of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology and Pain Research, University Hospital of Cologne, Robert Koch Str. 10, 50931 Cologne, Germany. joerg.isensee@uk-koeln.de tim.hucho@uk-koeln.de.
University College London · GB
Funding
Arthritis Research UKBiotechnology and Biological Sciences Research Council BB/F000227/1Medical Research Council G0901905Medical Research Council G9717869Wellcome Trust 065593Wellcome Trust 200183/Z/15/Z
Abstract
Genetic loss of the voltage-gated sodium channel Na
Indexed as
Signal TransductionAction PotentialsAnalgesics, OpioidAnimalsCyclic AMP-Dependent Protein Kinase RIIbeta SubunitGanglia, SpinalIndolesMaleMice, KnockoutNAV1.7 Voltage-Gated Sodium ChannelNociceptorsPainPatch-Clamp TechniquesRats, Sprague-DawleyReceptors, Opioid, muReceptors, Serotonin, 5-HT4Analgesics, OpioidCyclic AMP-Dependent Protein Kinase RIIbeta SubunitGR 113808IndolesNAV1.7 Voltage-Gated Sodium ChannelReceptors, Opioid, muReceptors, Serotonin, 5-HT4Scn9a protein, mouseSerotoninSerotonin AntagonistsSodium Channel BlockersSulfonamidesTetrodotoxin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT05603702ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.