ReviewBioscience reports2017
Sexual dimorphisms in genetic loci linked to body fat distribution.
Review in Bioscience reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Genetic Variation and Hot Flashes: A Systematic Review.The Journal of clinical endocrinology and metabolism · 2020Pooled it
- Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.Human molecular genetics · 2019Pooled it
- A scientometric review of genome-wide association studies.Communications biology · 2019Pooled it
- Difference in breast size between the first and third trimesters of pregnancy and changes in a woman's body size, subcutaneous fat tissue, and biochemical parameters.Scientific reports · 2026Article
- Considerations on mechanistic coherence and generalizability in the study of leptin G2548A variant and T2DM with CAD.Journal of diabetes investigation · 2026Article
- Triglyceride-glucose index and its combination with anthropometric obesity indicators are significant predictors of visceral obesity among the Newfoundland population.Scientific reports · 2025Article
- Sex and Gender Differences in Obesity: Biological, Sociocultural, and Clinical Perspectives.The world journal of men's health · 2025Review
- Association of Android and Gynoid Fatness With Incident Dementia and Brain Structure.Journal of cachexia, sarcopenia and muscle · 2025Article
- The Impact of Digital Technology-Based Exercise Combined With Dietary Intervention on Body Composition in College Students With Obesity: Prospective Study.Journal of medical Internet research · 2025Article
- Association between thyroid stimulating hormone levels and nonproliferative diabetic retinopathy: a cross-sectional study.BMC endocrine disorders · 2025Article
- Association between percent body fat and the risk of prediabetes among Chinese adults: a 5-years longitudinal cohort study.Scientific reports · 2025Article
- Effect of a Diet Supplemented with Marine Omega-3 Fatty Acids on Inflammatory Markers in Subjects with Obesity: A Randomized Active Placebo-Controlled Trial.Healthcare (Basel, Switzerland) · 2025Article
- Systems genetics analysis of human body fat distribution genes identifies adipocyte processes.Life science alliance · 2024Article
- The role of various physiological and bioelectrical parameters for estimating the weight status in infants and juveniles cohort from the Southern Cuba region: a machine learning study.BMC pediatrics · 2024Article
- Identifying latent genetic interactions in genome-wide association studies using multiple traits.Genome medicine · 2024Article
- The evolutionary impact and influence of oestrogens on adipose tissue structure and function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Sex-Specific Features of the Correlation between GWAS-Noticeable Polymorphisms and Hypertension in Europeans of Russia.International journal of molecular sciences · 2023Article
- Article
- The role of gonadal hormones and sex chromosomes in sex-dependent effects of early nutrition on metabolic health.Frontiers in endocrinology · 2023Review
- Development and validation of a diabetic retinopathy risk prediction model for middle-aged patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a chronic condition associated with increased morbidity and mortality and is a risk factor for a number of other diseases including type 2 diabetes and cardiovascular disease. Obesity confers an enormous, costly burden on both individuals and public health more broadly. Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes. Body fat distribution is distinct from overall obesity in measurement, but studies of body fat distribution can yield insights into the risk factors for and causes of overall obesity. Sexual dimorphism in body fat distribution is present throughout life. Though sexual dimorphism is subtle in early stages of life, it is attenuated in puberty and during menopause. This phenomenon could be, at least in part, due to the influence of sex hormones on the trait. Findings from recent large genome-wide association studies (GWAS) for various measures of body fat distribution (including waist-to-hip ratio, hip or waist circumference, trunk fat percentage and the ratio of android and gynoid fat percentage) emphasize the strong sexual dimorphism in the genetic regulation of fat distribution traits. Importantly, sexual dimorphism is not observed for overall obesity (as assessed by body mass index or total fat percentage). Notably, the genetic loci associated with body fat distribution, which show sexual dimorphism, are located near genes that are expressed in adipose tissues and/or adipose cells. Considering the epidemiological and genetic evidence, sexual dimorphism is a prominent feature of body fat distribution. Research that specifically focuses on sexual dimorphism in fat distribution can provide novel insights into human physiology and into the development of obesity and its comorbidities, as well as yield biological clues that will aid in the improvement of disease prevention and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.