ArticleThe Journal of antimicrobial chemotherapy2017
Spread of mcr-1-carrying Enterobacteriaceae in sewage water from Spain.
Article in The Journal of antimicrobial chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 69 citations in OpenAlex.
- Article
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- Bacterial Communities and Resistance and Virulence Genes in Hospital and Community Wastewater: Metagenomic Analysis.International journal of molecular sciences · 2025Article
- A Review of the Dissemination of Antibiotic Resistance through Wastewater Treatment Plants: Current Situation in Sri Lanka and Future Perspectives.Life (Basel, Switzerland) · 2024Review
- Presence and Persistence ofMicroorganisms · 2024Article
- Peptide MSI-1 inhibited MCR-1 and regulated outer membrane vesicles to combat immune evasion of Escherichia coli.Microbial biotechnology · 2023Article
- Antimicrobial resistance and molecular epidemiological analysis of Escherichia fergusonii harboring the mcr gene in pigs and broiler chickens in Okinawa, Japan.The Journal of veterinary medical science · 2023Article
- Wastewater treatment plants, an "escape gate" for ESCAPE pathogens.Frontiers in microbiology · 2023Review
- Prevalence of the colistin resistance geneAIMS microbiology · 2023Article
- Distribution and Antibiotic Resistance Characteristics of Bacteria Isolated from Blood Culture in a Teaching Hospital in Vietnam During 2014-2021.Infection and drug resistance · 2023Article
- Prevalence and molecular characterization of extended-spectrum β-lactamase (ESBL) producingIranian journal of veterinary research · 2022Article
- Comparative genomic characterization of multidrug-resistant Citrobacter spp. strains in Fennec fox imported to China.Gut pathogens · 2021Article
- Genomic features of a high-risk mcr-1.1-positive Escherichia coli ST10 isolated from cattle farm environment.Environmental science and pollution research international · 2021Article
- Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments.Communications biology · 2021Article
- Co-Occurrence of NDM-9 and MCR-1 in a Human Gut ColonizedInfection and drug resistance · 2021Article
- Antibiotic Resistance in Recreational Waters: State of the Science.International journal of environmental research and public health · 2020Review
- Multidrug-Resistant Bacteria Isolated from Different Aquatic Environments in the North of Spain and South of France.Microorganisms · 2020Article
- Occurrence and Characteristics of Mobile Colistin Resistance (International journal of environmental research and public health · 2020Review
- Prevalence of Colistin-Resistant, Carbapenem-Hydrolyzing Proteobacteria in Hospital Water Bodies and Out-Falls of West Bengal, India.International journal of environmental research and public health · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: The mobile colistin resistance gene mcr-1 has been identified worldwide in human and animal sources, while its occurrence in the environment is still largely unknown. The aim of this study was to investigate the presence of mcr-1 -harbouring Enterobacteriaceae in water samples obtained from rivers and waste water treatment plants in the area of Barcelona, Spain. Methods: The presence of mcr-1 was detected by PCR. Bacterial identification was performed via MALDI-TOF MS. Resistance to colistin was determined by a broth dilution method. The epidemiological relationship between the positive isolates was assessed with PFGE and ST was determined by MLST. Plasmid characterization was performed by transformation experiments, antimicrobial susceptibility testing and incompatibility group PCR. Results: Thirty MDR isolates bearing mcr-1 , 29 Escherichia coli (ST632 and ST479) and 1 Klebsiella pneumoniae (ST526), were identified in sewage from two different waste water treatment plants, whereas the gene was not found in river water. All isolates, including the K. pneumoniae , harboured bla CTX-M-55 and bla TEM-1 . mcr-1 was in all cases associated with an IncI2 plasmid, which only conferred resistance to colistin. mcr-1 was harboured by two predominant E. coli clones that were found in both waste water treatment plants. Conclusions: This study showed a high occurrence of mcr-1 in the sewage of Barcelona, mainly due to the dissemination of two E. coli pulsotypes that are circulating in the population. The presence of mcr-1 in the environment is a cause for concern, and suggests high prevalence of mcr-1 in the community.
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