Evidence map›Paper›PMID 28073846›Full record

Trial reportClinical cancer research : an official journal of the American Association for Cancer Research2017

Extended Treatment with Single-Agent Ibrutinib at the 420 mg Dose Leads to Durable Responses in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.

Steven E Coutré, Richard R Furman, Ian W Flinn, Jan A Burger, Kristie Blum, Jeff Sharman, Jeffrey Jones, William Wierda, Weiqiang Zhao, Nyla A Heerema and 7 more

Open access · bronzeAbstract readClinical Trial, Phase IClinical Trial, Phase II
In one paragraph

Trial report in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 61 citations in OpenAlex.

  1. Trial
  2. Trial
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  5. Review
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  9. Article
  10. Review
  11. Review
  12. Review
  13. The Evolution of Targeted Therapies in Chronic Lymphocytic Leukaemia.Current hematologic malignancy reports · 2020
    Review
  14. Ibrutinib dose modifications in the management of CLL.Journal of hematology & oncology · 2020
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Steven E CoutréStanford Cancer Center, Stanford University School of Medicine, Stanford, California. coutre@stanford.edu.
Richard R FurmanDepartment of Medicine, Weill Cornell Medical College, New York, New York.
Ian W FlinnSarah Cannon Research Institute, Nashville, Tennessee.
Jan A BurgerDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas.
Kristie BlumThe Ohio State University, Columbus, Ohio.
Jeff SharmanWillamette Valley Cancer Institute and Research Center/US Oncology Research, Springfield, Oregon.
Jeffrey JonesThe Ohio State University, Columbus, Ohio.
William WierdaDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas.
Weiqiang ZhaoThe Ohio State University, Columbus, Ohio.
Nyla A HeeremaThe Ohio State University, Columbus, Ohio.
Amy J JohnsonThe Ohio State University, Columbus, Ohio.
Anh TranPharmacyclics LLC, an AbbVie Company, Sunnyvale, California.
Cathy ZhouPharmacyclics LLC, an AbbVie Company, Sunnyvale, California.
Elizabeth BilottiPharmacyclics LLC, an AbbVie Company, Sunnyvale, California.
Danelle F JamesPharmacyclics LLC, an AbbVie Company, Sunnyvale, California.
John C ByrdThe Ohio State University, Columbus, Ohio.
Susan O'BrienDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, Texas.
The Ohio State University · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Stanford University NCTN- Network Lead Academic SiteU10CA180816 · NCI · STANFORD UNIVERSITY · PI COUTRE, STEVEN EDWARD, LE, QUYNH-THU XUAN · 2014 to 2018
$2.8M
NCI NIH HHS P30 CA016672NCI NIH HHS U10 CA180816
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdenineAgedAged, 80 and overDisease-Free SurvivalDose-Response Relationship, DrugDrug-Related Side Effects and Adverse ReactionsFemaleHumansLeukemia, Lymphocytic, Chronic, B-CellMalePiperidinesProtein Kinase InhibitorsPyrazolesPyrimidinesRemission InductionAdenineibrutinibPiperidinesProtein Kinase InhibitorsPyrazolesPyrimidines

Identifiers

PMID28073846
PMCPMC6317338
OpenAlexW2570921003

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.