Evidence map›Paper›PMID 28073841›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

Activation of EIF4E by Aurora Kinase A Depicts a Novel Druggable Axis in Everolimus-Resistant Cancer Cells.

Ahmed Katsha, Lihong Wang, Janet Arras, Omar M Omar, Jeffrey Ecsedy, Abbes Belkhiri, Wael El-Rifai

Abstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

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  17. Unraveling the rewired network.Nature chemical biology · 2018
    Article
  18. Article
  19. Article
  20. Exosomal microRNA Therapy for Non-Small-Cell Lung Cancer.Technology in cancer research & treatment
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Ahmed KatshaDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Lihong WangDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Janet ArrasDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Omar M OmarDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Jeffrey EcsedyTranslational Medicine, Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.
Abbes BelkhiriDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Wael El-RifaiDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee. wael.el-rifai@vanderbilt.edu.
Vanderbilt University Medical Center · USRaritan Valley Community College · USTakeda (Japan) · JPVA Tennessee Valley Healthcare System · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Understanding and Controlling p120 Dysfunction in CRCP50CA095103 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 2002 to 2017
$33.6M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Targets of Gene Overexpression at 17q in Gastric Tumorigenesis: Darpp32R01CA093999 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI EL-RIFAI, WAEL · 2002 to 2017
$4.5M
The Role of Aurora Kinase in Upper Gastrointestinal AdenocarcinomasR01CA131225 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI EL-RIFAI, WAEL · 2009 to 2018
$3.3M
Molecular Pathobiology of Gastric CarcinogenesisI01BX001179 · VA · VETERANS HEALTH ADMINISTRATION · PI EL-RIFAI, WAEL · 2012 to 2024
–
BLRD Research Career Scientist Award ApplicationIK6BX003787 · VA · VETERANS HEALTH ADMINISTRATION · PI WAEL EL-RIFAI · 2017 to 2026
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BLRD VA I01 BX001179BLRD VA IK6 BX003787NCI NIH HHS P30 CA068485NCI NIH HHS P50 CA095103NCI NIH HHS R01 CA093999NCI NIH HHS R01 CA131225NIDDK NIH HHS P30 DK058404
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdenocarcinomaAnimalsApoptosisAurora Kinase ACell SurvivalDrug Resistance, NeoplasmEukaryotic Initiation Factor-4EEverolimusGastrointestinal NeoplasmsGene Expression Regulation, NeoplasticHumansMiceProtein Kinase InhibitorsProto-Oncogene Proteins c-mycTOR Serine-Threonine KinasesXenograft Model Antitumor AssaysAURKA protein, humanAurora Kinase AEukaryotic Initiation Factor-4EEverolimusMTOR protein, humanMYC protein, humanProtein Kinase InhibitorsProto-Oncogene Proteins c-mycTOR Serine-Threonine Kinases

Identifiers

PMID28073841
PMCPMC5503809
OpenAlexW2570710829

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.