Evidence map›Paper›PMID 28073805›Full record

ArticleCirculation2017

Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading.

Thomas Seidel, Sutip Navankasattusas, Azmi Ahmad, Nikolaos A Diakos, Weining David Xu, Martin Tristani-Firouzi, Michael J Bonios, Iosif Taleb, Dean Y Li, Craig H Selzman and 2 more

Open access · bronzeAbstract read
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In one paragraph

Article in Circulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Nanoscale organization of cardiac calcium channels is dependent on thyroid hormone status.American journal of physiology. Heart and circulatory physiology · 2024
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  13. Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
  14. Serial block face scanning electron microscopy reveals region-dependent remodelling of transverse tubules post-myocardial infarction.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
  15. Review
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  18. Fibrosis and impaired CaBiophysical reviews · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Thomas SeidelFrom Nora Eccles Harrison Cardiovascular Research and Training Institute (T.S., A.A., M.T.-F., S.G.D., F.B.S.), Molecular Medicine Program (S.N., N.A.D., D.Y.L., C.H.S.), Department of Bioengineering (A.A., F.B.S.), Division of Cardiovascular Medicine (W.D.X., M.J.B., I.T., D.Y.L., S.G.D.), and Division of Cardiothoracic Surgery (C.H.S.), University of Utah, Salt Lake City. Dr Seidel is currently at the Institute for Cellular and Molecular Physiology, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Germany. thomas.seidel@fau.de stavros.drakos@hsc.utah.edu frank.sachse@utah.edu.
Sutip NavankasattusasFrom Nora Eccles Harrison Cardiovascular Research and Training Institute (T.S., A.A., M.T.-F., S.G.D., F.B.S.), Molecular Medicine Program (S.N., N.A.D., D.Y.L., C.H.S.), Department of Bioengineering (A.A., F.B.S.), Division of Cardiovascular Medicine (W.D.X., M.J.B., I.T., D.Y.L., S.G.D.), and Division of Cardiothoracic Surgery (C.H.S.), University of Utah, Salt Lake City. Dr Seidel is currently at the Institute for Cellular and Molecular Physiology, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Germany.
Azmi AhmadFrom Nora Eccles Harrison Cardiovascular Research and Training Institute (T.S., A.A., M.T.-F., S.G.D., F.B.S.), Molecular Medicine Program (S.N., N.A.D., D.Y.L., C.H.S.), Department of Bioengineering (A.A., F.B.S.), Division of Cardiovascular Medicine (W.D.X., M.J.B., I.T., D.Y.L., S.G.D.), and Division of Cardiothoracic Surgery (C.H.S.), University of Utah, Salt Lake City. Dr Seidel is currently at the Institute for Cellular and Molecular Physiology, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Germany.
Nikolaos A DiakosFrom Nora Eccles Harrison Cardiovascular Research and Training Institute (T.S., A.A., M.T.-F., S.G.D., F.B.S.), Molecular Medicine Program (S.N., N.A.D., D.Y.L., C.H.S.), Department of Bioengineering (A.A., F.B.S.), Division of Cardiovascular Medicine (W.D.X., M.J.B., I.T., D.Y.L., S.G.D.), and Division of Cardiothoracic Surgery (C.H.S.), University of Utah, Salt Lake City. Dr Seidel is currently at the Institute for Cellular and Molecular Physiology, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Germany.
Weining David XuFrom Nora Eccles Harrison Cardiovascular Research and Training Institute (T.S., A.A., M.T.-F., S.G.D., F.B.S.), Molecular Medicine Program (S.N., N.A.D., D.Y.L., C.H.S.), Department of Bioengineering (A.A., F.B.S.), Division of Cardiovascular Medicine (W.D.X., M.J.B., I.T., D.Y.L., S.G.D.), and Division of Cardiothoracic Surgery (C.H.S.), University of Utah, Salt Lake City. Dr Seidel is currently at the Institute for Cellular and Molecular Physiology, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Germany.
Martin Tristani-FirouziFrom Nora Eccles Harrison Cardiovascular Research and Training Institute (T.S., A.A., M.T.-F., S.G.D., F.B.S.), Molecular Medicine Program (S.N., N.A.D., D.Y.L., C.H.S.), Department of Bioengineering (A.A., F.B.S.), Division of Cardiovascular Medicine (W.D.X., M.J.B., I.T., D.Y.L., S.G.D.), and Division of Cardiothoracic Surgery (C.H.S.), University of Utah, Salt Lake City. Dr Seidel is currently at the Institute for Cellular and Molecular Physiology, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Germany.
Michael J BoniosFrom Nora Eccles Harrison Cardiovascular Research and Training Institute (T.S., A.A., M.T.-F., S.G.D., F.B.S.), Molecular Medicine Program (S.N., N.A.D., D.Y.L., C.H.S.), Department of Bioengineering (A.A., F.B.S.), Division of Cardiovascular Medicine (W.D.X., M.J.B., I.T., D.Y.L., S.G.D.), and Division of Cardiothoracic Surgery (C.H.S.), University of Utah, Salt Lake City. Dr Seidel is currently at the Institute for Cellular and Molecular Physiology, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Germany.
Iosif TalebFrom Nora Eccles Harrison Cardiovascular Research and Training Institute (T.S., A.A., M.T.-F., S.G.D., F.B.S.), Molecular Medicine Program (S.N., N.A.D., D.Y.L., C.H.S.), Department of Bioengineering (A.A., F.B.S.), Division of Cardiovascular Medicine (W.D.X., M.J.B., I.T., D.Y.L., S.G.D.), and Division of Cardiothoracic Surgery (C.H.S.), University of Utah, Salt Lake City. Dr Seidel is currently at the Institute for Cellular and Molecular Physiology, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Germany.
Dean Y LiFrom Nora Eccles Harrison Cardiovascular Research and Training Institute (T.S., A.A., M.T.-F., S.G.D., F.B.S.), Molecular Medicine Program (S.N., N.A.D., D.Y.L., C.H.S.), Department of Bioengineering (A.A., F.B.S.), Division of Cardiovascular Medicine (W.D.X., M.J.B., I.T., D.Y.L., S.G.D.), and Division of Cardiothoracic Surgery (C.H.S.), University of Utah, Salt Lake City. Dr Seidel is currently at the Institute for Cellular and Molecular Physiology, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Germany.
Craig H SelzmanFrom Nora Eccles Harrison Cardiovascular Research and Training Institute (T.S., A.A., M.T.-F., S.G.D., F.B.S.), Molecular Medicine Program (S.N., N.A.D., D.Y.L., C.H.S.), Department of Bioengineering (A.A., F.B.S.), Division of Cardiovascular Medicine (W.D.X., M.J.B., I.T., D.Y.L., S.G.D.), and Division of Cardiothoracic Surgery (C.H.S.), University of Utah, Salt Lake City. Dr Seidel is currently at the Institute for Cellular and Molecular Physiology, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Germany.
Stavros G DrakosFrom Nora Eccles Harrison Cardiovascular Research and Training Institute (T.S., A.A., M.T.-F., S.G.D., F.B.S.), Molecular Medicine Program (S.N., N.A.D., D.Y.L., C.H.S.), Department of Bioengineering (A.A., F.B.S.), Division of Cardiovascular Medicine (W.D.X., M.J.B., I.T., D.Y.L., S.G.D.), and Division of Cardiothoracic Surgery (C.H.S.), University of Utah, Salt Lake City. Dr Seidel is currently at the Institute for Cellular and Molecular Physiology, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Germany. thomas.seidel@fau.de stavros.drakos@hsc.utah.edu frank.sachse@utah.edu.
Frank B SachseFrom Nora Eccles Harrison Cardiovascular Research and Training Institute (T.S., A.A., M.T.-F., S.G.D., F.B.S.), Molecular Medicine Program (S.N., N.A.D., D.Y.L., C.H.S.), Department of Bioengineering (A.A., F.B.S.), Division of Cardiovascular Medicine (W.D.X., M.J.B., I.T., D.Y.L., S.G.D.), and Division of Cardiothoracic Surgery (C.H.S.), University of Utah, Salt Lake City. Dr Seidel is currently at the Institute for Cellular and Molecular Physiology, Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Germany. thomas.seidel@fau.de stavros.drakos@hsc.utah.edu frank.sachse@utah.edu.
Norwegian Womens Public Health Association · NOAnna Needs Neuroblastoma Answers · US

Funding

UNIVERSITY OF UTAH CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE-UL1: BPCAUL1RR025764 · NCRR · UNIVERSITY OF UTAH · PI MCCLAIN, DONALD A. · 2008 to 2011
$19.4M
TRAINING IN CARDIOVASCULAR RESEARCHT32HL007576 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos, Robin M Shaw · 1985 to 2026
$10.6M
Remodeling of the Transverse Tubular System and Ryanodine Receptor Clusters in DyR01HL094464 · NHLBI · UNIVERSITY OF UTAH · PI SACHSE, FRANK BERND · 2010 to 2014
$1.9M
Clinical and Metabolic Signature of Recovered Myocardium in Human Heart FailureR01HL135121 · NHLBI · UNIVERSITY OF UTAH · PI DRAKOS, STAVROS GEORGE · 2017 to 2021
$1.9M
Cellular Remodeling in Heart Failure and after LVAD UnloadingR01HL132067 · NHLBI · UNIVERSITY OF UTAH · PI DRAKOS, STAVROS GEORGE, SACHSE, FRANK BERND · 2017 to 2020
$1.5M
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR011234 · NCRR · UNIVERSITY OF UTAH · PI MATSEN, JOHN M · 1995 to 1995
–
NCRR NIH HHS C06 RR011234NCRR NIH HHS UL1 RR025764NHLBI NIH HHS R01 HL094464NHLBI NIH HHS R01 HL132067NHLBI NIH HHS R01 HL135121NHLBI NIH HHS T32 HL007576
6 · The paper itself

Abstract

backgroundCardiac recovery in response to mechanical unloading by left ventricular assist devices (LVADs) has been demonstrated in subgroups of patients with chronic heart failure (HF). Hallmarks of HF are depletion and disorganization of the transverse tubular system (t-system) in cardiomyocytes. Here, we investigated remodeling of the t-system in human end-stage HF and its role in cardiac recovery.

methodsLeft ventricular biopsies were obtained from 5 donors and 26 patients with chronic HF undergoing implantation of LVADs. Three-dimensional confocal microscopy and computational image analysis were applied to assess t-system structure, density, and distance of ryanodine receptor clusters to the sarcolemma, including the t-system. Recovery of cardiac function in response to mechanical unloading was assessed by echocardiography during turndown of the LVAD.

resultsThe majority of HF myocytes showed remarkable t-system remodeling, particularly sheet-like invaginations of the sarcolemma. Circularity of t-system components was decreased in HF versus controls (0.37±0.01 versus 0.46±0.02;

conclusionsThe t-system in end-stage human HF presents a characteristic novel phenotype consisting of sheet-like invaginations of the sarcolemma. Our results suggest that the remodeled t-system impairs excitation-contraction coupling and functional recovery during chronic LVAD unloading. An intact t-system at the time of LVAD implantation may constitute a precondition and predictor for functional cardiac recovery after mechanical unloading.

Indexed as

Excitation Contraction CouplingHeart-Assist DevicesMyocardial ContractionVentricular Function, LeftVentricular RemodelingAdultAgedBiopsyCase-Control StudiesEchocardiographyFemaleHeart FailureHumansImage Processing, Computer-AssistedMaleMicroscopy, ConfocalRyanodine Receptor Calcium Release Channelexcitation contraction couplingheart failuremyocytes, cardiacrecovery of functionryanodine receptor calcium release channels

Identifiers

PMID28073805
PMCPMC5404964
OpenAlexW2569513212

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.