ArticleBrain : a journal of neurology2017
Dynamics of convulsive seizure termination and postictal generalized EEG suppression.
Article in Brain : a journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- A cloud-based miniscope for neurosurveillance of brain health and disease in freely behaving animals.Nature methods · 2026Article
- Postictal electroencephalographic suppression in generalized tonic-clonic seizures: clinical correlates and predictive factors from a cross-sectional observational study.Epilepsy & behavior reports · 2026Article
- Stabilizing fractional dynamical networks suppresses epileptic seizures.Scientific reports · 2026Article
- Automated analysis of postictal generalized electroencephalogram suppression for SUDEP risk stratification.Epilepsia open · 2026Article
- Cardiorespiratory cross-frequency coupling biomarker for sudden unexpected death in epilepsy.Epilepsia · 2026Article
- H- and m-channel overexpression promotes seizure-like events by impairing the ability of inhibitory neurons to process correlated inputs.PLoS computational biology · 2025Article
- Allopregnanolone and progesterone in relation to a single electroconvulsive therapy seizure and subsequent clinical outcome: an observational cohort study.BMC psychiatry · 2024Observational
- Highly local activation of inhibition at the seizure wavefront in vivo.Cell reports · 2024Article
- Seizure onset and offset pattern determine the entrainment of the cortex and substantia nigra in the nonhuman primate model of focal temporal lobe seizures.bioRxiv : the preprint server for biology · 2024Article
- Article
- An exploratory computational analysis in mice brain networks of widespread epileptic seizure onset locations along with potential strategies for effective intervention and propagation control.Frontiers in computational neuroscience · 2024Article
- A simple, automated method of seizure detection in mouse models of temporal lobe epilepsy.Epilepsy research · 2023Article
- Functional connectivity discriminates epileptogenic states and predicts surgical outcome in children with drug resistant epilepsy.Scientific reports · 2023Article
- Quiescence during burst suppression and postictal generalized EEG suppression are distinct patterns of activity.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Article
- Focal seizures are organized by feedback between neural activity and ion concentration changes.eLife · 2022Article
- Quantifying seizure termination patterns reveals limited pathways to seizure end.Neurobiology of disease · 2022Article
- A Peri-Ictal EEG-Based Biomarker for Sudden Unexpected Death in Epilepsy (SUDEP) Derived From Brain Network Analysis.Frontiers in network physiology · 2022Article
- Interictal EEG and ECG for SUDEP Risk Assessment: A Retrospective Multicenter Cohort Study.Frontiers in neurology · 2022Article
- Headache in people with epilepsy.Nature reviews. Neurology · 2021Review
- Temporally Targeted Interactions With Pathologic Oscillations as Therapeutical Targets in Epilepsy and Beyond.Frontiers in neural circuits · 2021Review
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9 authors.
Funding
Abstract
It is not fully understood how seizures terminate and why some seizures are followed by a period of complete brain activity suppression, postictal generalized EEG suppression. This is clinically relevant as there is a potential association between postictal generalized EEG suppression, cardiorespiratory arrest and sudden death following a seizure. We combined human encephalographic seizure data with data of a computational model of seizures to elucidate the neuronal network dynamics underlying seizure termination and the postictal generalized EEG suppression state. A multi-unit computational neural mass model of epileptic seizure termination and postictal recovery was developed. The model provided three predictions that were validated in EEG recordings of 48 convulsive seizures from 48 subjects with refractory focal epilepsy (20 females, age range 15-61 years). The duration of ictal and postictal generalized EEG suppression periods in human EEG followed a gamma probability distribution indicative of a deterministic process (shape parameter 2.6 and 1.5, respectively) as predicted by the model. In the model and in humans, the time between two clonic bursts increased exponentially from the start of the clonic phase of the seizure. The terminal interclonic interval, calculated using the projected terminal value of the log-linear fit of the clonic frequency decrease was correlated with the presence and duration of postictal suppression. The projected terminal interclonic interval explained 41% of the variation in postictal generalized EEG suppression duration (P < 0.02). Conversely, postictal generalized EEG suppression duration explained 34% of the variation in the last interclonic interval duration. Our findings suggest that postictal generalized EEG suppression is a separate brain state and that seizure termination is a plastic and autonomous process, reflected in increased duration of interclonic intervals that determine the duration of postictal generalized EEG suppression.
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