Evidence map›Paper›PMID 28073635›Full record

ArticleDNA repair2017

PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions.

Rosemary H C Wilson, Antonio J Biasutto, Lihao Wang, Roman Fischer, Emma L Baple, Andrew H Crosby, Erika J Mancini, Catherine M Green

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in DNA repair, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Rosemary H C WilsonWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
Antonio J BiasuttoDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
Lihao WangWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
Roman FischerTarget Discovery Institute, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK.
Emma L BapleUniversity of Exeter Medical School, Barrack Road, Exeter, EX2 5DW, UK.
Andrew H CrosbyUniversity of Exeter Medical School, Barrack Road, Exeter, EX2 5DW, UK.
Erika J ManciniDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK; School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9RH, UK.
Catherine M GreenWellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK. Electronic address: catherine.green@well.ox.ac.uk.
Centre for Human Genetics · GBUniversity of Exeter · GBUniversity of Oxford · GB

Funding

Medical Research Council G1001931Medical Research Council G1002279Medical Research Council MR/L006812/1Wellcome Trust 090532/Z/09/ZWellcome Trust 099667/Z/12/Z
6 · The paper itself

Abstract

Proliferating cell nuclear antigen (PCNA) is an essential cofactor for DNA replication and repair, recruiting multiple proteins to their sites of action. We examined the effects of the PCNA

Indexed as

DNA RepairDNA ReplicationMutation, MissenseCell Cycle ProteinsDNA Polymerase IIIDNA Repair-Deficiency DisordersHumansMultiprotein ComplexesProliferating Cell Nuclear AntigenProtein BindingProtein Interaction Domains and MotifsUbiquitinationCDT1 protein, humanCell Cycle ProteinsDNA Polymerase IIIMultiprotein ComplexesPOLD3 protein, humanPOLD4 protein, humanProliferating Cell Nuclear AntigenDNA repairDNA replicationPCNAPCNA-associated repair disorder (PARD)

Identifiers

PMID28073635
PMCPMC5264654
OpenAlexW2565963834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.