Evidence map›Paper›PMID 28073366›Full record

ArticleBMC medicine2017

Oral treatment with Lactobacillus rhamnosus attenuates behavioural deficits and immune changes in chronic social stress.

Aadil Bharwani, M Firoz Mian, Michael G Surette, John Bienenstock, Paul Forsythe

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Probiotics for the treatment of depression and its comorbidities: A systemic review.Frontiers in cellular and infection microbiology · 2023
    Pooled it
  3. Pooled it
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  5. PsychobioticFrontiers in immunology · 2023
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  7. Nutrients · 2026
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aadil BharwaniDepartment of Pathology & Molecular Medicine, McMaster University, Hamilton, Canada.
M Firoz MianMcMaster Brain-Body Institute, The Research Institute of St. Joseph's Hamilton, Hamilton, Canada.
Michael G SuretteDepartment of Medicine, McMaster University, The Brain-Body Institute, 50 Charlton Avenue East, T3302, Hamilton, Ontario, L8N 4A6, Canada.
John BienenstockDepartment of Pathology & Molecular Medicine, McMaster University, Hamilton, Canada.
Paul ForsytheMcMaster Brain-Body Institute, The Research Institute of St. Joseph's Hamilton, Hamilton, Canada. forsytp@mcmaster.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStress-related disorders involve systemic alterations, including disruption of the intestinal microbial community. Given the putative connections between the microbiota, immunity, neural function, and behaviour, we investigated the potential for microbe-induced gut-to-brain signalling to modulate the impact of stress on host behaviour and immunoregulation.

methodsMale C57BL/6 mice treated orally over 28 days with either Lactobacillus rhamnosus (JB-1) ™ or vehicle were subjected to chronic social defeat and assessed for alterations in behaviour and immune cell phenotype. 16S rRNA sequencing and mass spectrometry were employed to analyse the faecal microbial community and metabolite profile.

resultsTreatment with JB-1 decreased stress-induced anxiety-like behaviour and prevented deficits in social interaction with conspecifics. However, JB-1 did not alter development of aggressor avoidance following social defeat. Microbial treatment attenuated stress-related activation of dendritic cells while increasing IL-10+ regulatory T cells. Furthermore, JB-1 modulated the effect of stress on faecal metabolites with neuroactive and immunomodulatory properties. Exposure to social defeat altered faecal microbial community composition and reduced species richness and diversity, none of which was prevented by JB-1. Stress-related microbiota disruptions persisted in vehicle-treated mice for 3 weeks following stressor cessation.

conclusionsThese data demonstrate that despite the complexity of the gut microbiota, exposure to a single microbial strain can protect against certain stress-induced behaviours and systemic immune alterations without preventing dysbiosis. This work supports microbe-based interventions for stress-related disorders.

Indexed as

Lacticaseibacillus rhamnosusAnimalsAnxietyBehavior, AnimalBrainGastrointestinal MicrobiomeInterleukin-10MaleMiceMice, Inbred C57BLProbioticsRNA, Ribosomal, 16SStress, PsychologicalInterleukin-10RNA, Ribosomal, 16SBehaviourChronic social defeatGut-brain axisImmune systemMicrobiotaPsychiatric disease

Identifiers

PMID28073366
PMCPMC5225647

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.