ArticleJournal of intensive care medicine2019
Safety of the Peripheral Administration of Vasopressor Agents.
Article in Journal of intensive care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- Incidence of Adverse Events in Peripheral Intravenous Vasopressor Use: A Systematic Review and Meta-Analysis.JAMA network open · 2026Pooled it
- Adverse events associated with administration of vasopressor medications through a peripheral intravenous catheter: a systematic review and meta-analysis.Critical care (London, England) · 2021Pooled it
- Liberal Versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial.Annals of emergency medicine · 2018Pooled it
- Perioperative Intravenous Infiltration: From Recognition to Prevention.Anesthesiology open · 2026Article
- The Implementation Gap in Early Septic Shock Resuscitation: A Three-Barrier Framework.Journal of clinical medicine · 2026Article
- Navigating the veins: A comprehensive review of vasoactive agent infusionWorld journal of critical care medicine · 2026Review
- The Influence of Vasopressor-Induced Arterial Blood Pressure Elevation on Muscle-Recorded Motor Evoked Potentials.Anesthesia and analgesia · 2026Observational
- Safety of Administration of Vasopressors Through Peripheral Compared to Central Venous Catheters in a Rural Kenyan Hospital: Protocol for a Prospective Observational Cohort Study.JMIR research protocols · 2026Observational
- Utility of a Peripheral Intravenous Catheter for Administration of Vasopressors: A Narrative Review.Cureus · 2026Review
- Resuscitation Targets, Fluids, and Vasoactives in Septic Shock.Clinics in chest medicine · 2026Review
- Perioperative Vasopressor Management in Noncardiac Surgical Patients.Anesthesiology · 2026Article
- Extravasation, thrombosis, and infection with vasopressor infusion through peripheral intravenous catheters: a systematic review and meta-analysis.Cardiovascular diagnosis and therapy · 2025Article
- Overview of Peripheral Vasopressor Use in an Academic Health System.Annals of the American Thoracic Society · 2025Article
- Latissimus Dorsi Flap for Chemotherapy-induced Extensive Forearm Necrosis: Case Study.Plastic and reconstructive surgery. Global open · 2025Article
- A randomised, controlled, feasibility trial comparing vasopressors infused via peripheral cannula versus central venous access for critically ill adults: The VIPCA trial.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- Early initiated noradrenaline versus fluid therapy for hypotension and shock in the emergency department (VASOSHOCK): a protocol for a pragmatic, multi-center, superiority, randomized controlled trial.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- The current use of vasoactive agents in cardiogenic shock related to myocardial infarction and acute decompensated heart failure.American heart journal plus : cardiology research and practice · 2025Article
- Just the facts: peripheral vasopressors.CJEM · 2025Article
- [Ten key statements on the guideline "Peripheral administration of vasopressors"].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Review
- Pre-hospital 'dirty adrenaline': A descriptive case series of patients receiving peripheral dilute adrenaline infusions in Central Australian remote nurse-led clinics prior to aeromedical retrieval.Emergency medicine Australasia : EMA · 2025Article
Corrections and comments
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vasopressors are an integral component of the management of septic shock and are traditionally given via a central venous catheter (CVC) due to the risk of tissue injury and necrosis if extravasated. However, the need for a CVC for the management of septic shock has been questioned, and the risk of extravasation and incidence of severe injury when vasopressors are given via a peripheral venous line (PVL) remains poorly defined. We performed a retrospective chart review of 202 patients who received vasopressors through a PVL. The objective was to describe the vasopressors administered peripherally, PVL size and location, the incidence of extravasation events, and the management of extravasation events. The primary vasopressors used were norepinephrine and phenylephrine. The most common PVL sites used were the forearm and antecubital fossa. The incidence of extravasation was 4%. All of the events were managed conservatively; none required an antidote or surgical management. Vasopressors were restarted at another peripheral site in 88% of the events. The incidence of extravasation was similar to prior studies. The use of a PVL for administration of vasopressors can be considered in patients with a contraindication to a CVC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.