Evidence map›Paper›PMID 28073155›Full record

ArticleMuscle & nerve2017

Differential effects of myostatin deficiency on motor and sensory axons.

Maria R Jones, Eric Villalón, Adam J Northcutt, Nigel A Calcutt, Michael L Garcia

Abstract readComparative Study
In one paragraph

Article in Muscle & nerve, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria R JonesDepartment of Biological Sciences, University of Missouri, Columbia, Missouri, USA.
Eric VillalónDepartment of Biological Sciences, University of Missouri, Columbia, Missouri, USA.
Adam J NorthcuttDepartment of Biological Sciences, University of Missouri, Columbia, Missouri, USA.
Nigel A CalcuttDepartment of Pathology, University of California San Diego, La Jolla, California, USA.
Michael L GarciaDepartment of Biological Sciences, University of Missouri, Columbia, Missouri, USA.

Funding

MINORITY BIOMEDICAL RESEARCHERS TRAINING INITIATIVER25GM056901 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI HANNINK, MARK · 1999 to 2019
$8.4M
MOLECULAR BASIS OF GENE EXPRESSION AND SIGNAL PROCESSINGT32GM008396 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI HANNINK, MARK · 1991 to 2021
$4.1M
Cholinergic constraint and diabetic neuropathyR01NS081082 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CALCUTT, NIGEL A. · 2013 to 2017
$1.6M
Mechanisms of disease pathogenesis in neurofilament linked Charcot-Marie-Tooth diR03NS060073 · NINDS · UNIVERSITY OF MISSOURI-COLUMBIA · PI GARCIA, MICHAEL L · 2008 to 2009
$142k
NIGMS NIH HHS R25 GM056901NIGMS NIH HHS T32 GM008396NINDS NIH HHS R01 NS081082NINDS NIH HHS R03 NS060073
6 · The paper itself

Abstract

introductionDeletion of myostatin in mice (MSTN

methodsUsing the MSTN

resultsAxon diameter and myelin thickness were increased in motor axons of MSTN DISCUSSION: These results suggest that motor and sensory axons establish structural properties by independent mechanisms. Moreover, in motor axons, instructive cues from the neuromuscular junction may play a role in co-regulating axon diameter and myelin thickness, whereas internode length is established independently. Muscle Nerve 56: E100-E107, 2017.

Indexed as

AnimalsAxonsMiceMice, Inbred C57BLMice, KnockoutMotor NeuronsMyostatinNeural ConductionSensory Receptor CellsMstn protein, mouseMyostatinaxon diameterinnervation fieldinternode lengthmyelin thicknessmyostatin deficiencynerve conduction velocity

Identifiers

PMID28073155
PMCPMC5503820

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.