Evidence map›Paper›PMID 28072873›Full record

ArticlePloS one2017

Association Study with 77 SNPs Confirms the Robust Role for the rs10830963/G of MTNR1B Variant and Identifies Two Novel Associations in Gestational Diabetes Mellitus Development.

Klara Rosta, Zahra Al-Aissa, Orsolya Hadarits, Jürgen Harreiter, Ákos Nádasdi, Fanni Kelemen, Dagmar Bancher-Todesca, Zsolt Komlósi, László Németh, János Rigó and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 4 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Association ofBiomolecules & biomedicine · 2025
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  15. A Simplified Screening Model to Predict the Risk of Gestational Diabetes Mellitus in Pregnant Chinese Women.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Klara RostaDepartment of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
Zahra Al-Aissa2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
Orsolya Hadarits1st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
Jürgen HarreiterGender Medicine Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Ákos Nádasdi2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
Fanni KelemenUniversity of Szeged, Faculty of Medicine, Szeged, Hungary.
Dagmar Bancher-TodescaDepartment of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
Zsolt KomlósiDepartment of Pulmonology, Semmelweis University, Budapest, Hungary.
László NémethDepartment of Probability Theory and Statistics, Eötvös Loránd University, Budapest, Hungary.
János Rigó1st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
István SzillerDepartment of Obstetrics and Gynecology, Szent Imre Teaching Hospital, Budapest, Hungary.
Anikó Somogyi2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
Alexandra Kautzky-WillerGender Medicine Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Gábor Firneisz2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
Semmelweis University · HUMedical University of Vienna · ATEötvös Loránd University · HUSzent Imre Egyetemi Oktatókórház · HUUniversity of Szeged · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextGenetic variation in human maternal DNA contributes to the susceptibility for development of gestational diabetes mellitus (GDM).

objectiveWe assessed 77 maternal single nucleotide gene polymorphisms (SNPs) for associations with GDM or plasma glucose levels at OGTT in pregnancy.

methods960 pregnant women (after dropouts 820: case/control: m99'WHO: 303/517, IADPSG: 287/533) were enrolled in two countries into this case-control study. After genomic DNA isolation the 820 samples were collected in a GDM biobank and assessed using KASP (LGC Genomics) genotyping assay. Logistic regression risk models were used to calculate ORs according to IADPSG/m'99WHO criteria based on standard OGTT values.

resultsThe most important risk alleles associated with GDM were rs10830963/G of MTNR1B (OR = 1.84/1.64 [IADPSG/m'99WHO], p = 0.0007/0.006), rs7754840/C (OR = 1.51/NS, p = 0.016) of CDKAL1 and rs1799884/T (OR = 1.4/1.56, p = 0.04/0.006) of GCK. The rs13266634/T (SLC30A8, OR = 0.74/0.71, p = 0.05/0.02) and rs7578326/G (LOC646736/IRS1, OR = 0.62/0.60, p = 0.001/0.006) variants were associated with lower risk to develop GDM. Carrying a minor allele of rs10830963 (MTNR1B); rs7903146 (TCF7L2); rs1799884 (GCK) SNPs were associated with increased plasma glucose levels at routine OGTT.

conclusionsWe confirmed the robust association of MTNR1B rs10830963/G variant with GDM binary and glycemic traits in this Caucasian case-control study. As novel associations we report the minor, G allele of the rs7578326 SNP in the LOC646736/IRS1 region as a significant and the rs13266634/T SNP (SLC30A8) as a suggestive protective variant against GDM development. Genetic susceptibility appears to be more preponderant in individuals who meet both the modified 99'WHO and the IADPSG GDM diagnostic criteria.

Indexed as

Polymorphism, Single NucleotideAdultCase-Control StudiesCation Transport ProteinsDiabetes, GestationalFemaleHumansInsulin Receptor Substrate ProteinsPregnancyReceptor, Melatonin, MT2Zinc Transporter 8Cation Transport ProteinsInsulin Receptor Substrate ProteinsIRS1 protein, humanMTNR1B protein, humanReceptor, Melatonin, MT2SLC30A8 protein, humanZinc Transporter 8

Identifiers

PMID28072873
PMCPMC5224877
OpenAlexW2569699994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.