Evidence map›Paper›PMID 28072871›Full record

ArticlePloS one2017

Atrophic and Metaplastic Progression in the Background Mucosa of Patients with Gastric Adenoma.

Hee Kyong Na, Charles J Cho, Suh Eun Bae, Jeong Hoon Lee, Young Soo Park, Ji Yong Ahn, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Observational
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Hee Kyong NaDepartment of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Charles J ChoDepartment of Biomedical Science, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Suh Eun BaeHealth Screening and Promotion Center, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Jeong Hoon LeeDepartment of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Young Soo ParkDepartment of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Ji Yong AhnDepartment of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Do Hoon KimDepartment of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Kee Don ChoiDepartment of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Ho June SongDepartment of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Gin Hyug LeeDepartment of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Se Jin JangDepartment of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Hwoon-Yong JungDepartment of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Ulsan College · KRUniversity of Ulsan · KRAsan Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn patients with adenoma, assessing premalignant changes in the surrounding mucosa is important for surveillance. This study evaluated atrophic and metaplastic progression in the background mucosa of adenoma or early gastric cancer (EGC) cases.

methodsAmong 146 consecutive patients who underwent endoscopic resection for intestinal-type gastric neoplasia, the adenoma group included 56 patients with low-grade dysplasia and the ECG group included 90 patients with high-grade dysplasia or invasive carcinoma. For histology, 3 paired biopsies were obtained from the antrum, corpus lesser curvature (CLC), and corpus greater curvature (CGC). Serological atrophy was determined based on pepsinogen A (PGA), progastricsin (PGC), gastrin-17, and total ghrelin levels. Topographic progression of atrophy and/or metaplasia was staged using the operative link on gastritis assessment (OLGA) and operative link on gastric intestinal metaplasia assessment (OLGIM) systems.

resultsRates of moderate-to-marked histological atrophy/metaplasia in patients with adenoma were 52.7%/78.2% at the antrum (vs. 58.8%/76.4% in EGC group), 63.5%/75.0% at the CLC (vs. 60.2%/69.7% in EGC group), and 10.9%/17.9% at the CGC (vs. 5.6%/7.8% in EGC group). Serological atrophy indicated by PGA and PGC occurred in 23.2% and 15.6% of cases in the adenoma and ECG groups, respectively (p = 0.25). Mean serum gastrin-17 concentrations of the adenoma group and EGC group were 10.4 and 9.0 pmol/L, respectively (p = 0.54). Mean serum total ghrelin levels were 216.6 and 209.5 pg/mL, respectively (p = 0.71). Additionally, between group rates of stage III-IV OLGA and OLGIM were similar (25.9% vs. 25.0%, p = 0.90; 41.8% vs. 44.9%, p = 0.71, respectively).

conclusionsAtrophic and metaplastic progression is extensive and severe in gastric adenoma patients. A surveillance strategy for metachronous tumors should be applied similarly for patients with adenoma or EGC.

Indexed as

AdenomaAgedBiomarkersDisease ProgressionFemaleFollow-Up StudiesGastric MucosaGastrinsGastritis, AtrophicHumansMaleMetaplasiaMiddle AgedNeoplasms, Second PrimaryPepsinogen CRisk FactorsBiomarkersgastrin 17GastrinsPepsinogen C

Identifiers

PMID28072871
PMCPMC5225017
OpenAlexW2570438195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.