Observational studyPloS one2017
Point-of-Care Versus Central Laboratory Measurements of Hemoglobin, Hematocrit, Glucose, Bicarbonate and Electrolytes: A Prospective Observational Study in Critically Ill Patients.
Observational study in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 62 citations in OpenAlex.
- Serum chloride concentration and outcomes in adults receiving intravenous fluid therapy with a balanced crystalloid solution or 0.9% sodium chloride.Intensive care medicine · 2025Trial
- Comparison of Sodium, Potassium, Hemoglobin, and Glucose Levels by Blood Gas Analyzer and Hospital Laboratory Autoanalyzer in Emergency Department Settings: A Cross-sectional Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Article
- Comparative analysis of hemoglobin, potassium, sodium, and glucose in arterial blood gas and venous blood of patients with COPD.Scientific reports · 2024Article
- Article
- A Wolf in Sheep's Clothing: Reuse of Routinely Obtained Laboratory Data in Research.Journal of medical Internet research · 2022Article
- The clinical effect of glucose meter selection upon the detection of neonatal hypoglycemia.Paediatrics & child health · 2022Article
- Agreement of Potassium, Sodium, Glucose, and Hemoglobin Measured by Blood Gas Analyzer With Dry Chemistry Analyzer and Complete Blood Count Analyzer: A Two-Center Retrospective Analysis.Frontiers in medicine · 2022Article
- Serum bicarbonate is associated with kidney outcomes in autosomal dominant polycystic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021Article
- Sex differences in electrolyte imbalances caused by SARS-CoV-2: A cross-sectional study.International journal of clinical practice · 2021Article
- Article
- Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue.PLoS neglected tropical diseases · 2021Article
- Evaluation of Hematocrit in Adults with Dengue by a Laboratory Information System.Journal of tropical medicine · 2021Article
- [Cardiac arrest under special circumstances].Notfall & rettungsmedizin · 2021Review
- Are Serum Potassium and Magnesium Levels Associated with Atrial Fibrillation After Cardiac Surgery?Journal of cardiothoracic and vascular anesthesia · 2020Observational
- Point-of-care versus central testing of hemoglobin during large volume blood transfusion.BMC anesthesiology · 2019Article
- Glucose Management Technologies for the Critically Ill.Journal of diabetes science and technology · 2019Review
- Interchangeability of Sodium and Potassium Result Values of Arterial Blood Gas with Laboratory Analyzer: Narrative Review.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2019Article
- Concordance between point-of-care blood gas analysis and laboratory autoanalyzer in measurement of hemoglobin and electrolytes in critically ill patients.Journal of clinical laboratory analysis · 2018Article
- Metabolism-Driven High-Throughput Cancer Identification with GLUT5-Specific Molecular Probes.Biosensors · 2018Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRapid detection of abnormal biological values using point-of-care (POC) testing allows clinicians to promptly initiate therapy; however, there are concerns regarding the reliability of POC measurements. We investigated the agreement between the latest generation blood gas analyzer and central laboratory measurements of electrolytes, bicarbonate, hemoglobin, hematocrit, and glucose.
methods314 paired samples were collected prospectively from 51 critically ill patients. All samples were drawn simultaneously in the morning from an arterial line. BD Vacutainer tubes were analyzed in the central laboratory using Beckman Coulter analyzers (AU 5800 and DxH 800). BD Preset 3 ml heparinized-syringes were analyzed immediately in the ICU using the POC Siemens RAPIDPoint 500 blood gas system. We used CLIA proficiency testing criteria to define acceptable analytical performance and interchangeability.
resultsBiases, limits of agreement (±1.96 SD) and coefficients of correlation were respectively: 1.3 (-2.2 to 4.8 mmol/L, r = 0.936) for sodium; 0.2 (-0.2 to 0.6 mmol/L, r = 0.944) for potassium; -0.9 (-3.7 to 2 mmol/L, r = 0.967) for chloride; 0.8 (-1.9 to 3.4 mmol/L, r = 0.968) for bicarbonate; -11 (-30 to 9 mg/dL, r = 0.972) for glucose; -0.8 (-1.4 to -0.2 g/dL, r = 0.985) for hemoglobin; and -1.1 (-2.9 to 0.7%, r = 0.981) for hematocrit. All differences were below CLIA cut-off values, except for hemoglobin.
conclusionsCompared to central Laboratory analyzers, the POC Siemens RAPIDPoint 500 blood gas system satisfied the CLIA criteria of interchangeability for all tested parameters, except for hemoglobin. These results are warranted for our own procedures and devices. Bearing these restrictions, we recommend clinicians to initiate an appropriate therapy based on POC testing without awaiting a control measurement.
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