ArticleBritish journal of cancer2017
CYP3A7*1C allele is associated with reduced levels of 2-hydroxylation pathway oestrogen metabolites.
Article in British journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Continuum of Host-Gut Microbial Co-metabolism: Host CYP3A4/3A7 are Responsible for Tertiary Oxidations of Deoxycholate Species.Drug metabolism and disposition: the biological fate of chemicals · 2019Trial
- BMI-Dependent Correlations of Sex Hormone Genes with Simple Endometrial Hyperplasia.Life (Basel, Switzerland) · 2026Article
- Exploring the impact of 3,3'-diindolylmethane on the urinary estrogen profile of premenopausal women.BMC complementary medicine and therapies · 2024Article
- Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism.Archives of biochemistry and biophysics · 2019Review
- Analytical Validation of Variants to Aid in Genotype-Guided Therapy for Oncology.The Journal of molecular diagnostics : JMD · 2019Article
- Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users.Obstetrics and gynecology · 2019Article
- Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics.Human molecular genetics · 2018Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundEndogenous sex hormones are well-established risk factors for breast cancer; the contribution of specific oestrogen metabolites (EMs) and/or ratios of specific EMs is less clear. We have previously identified a CYP3A7*1C allele that is associated with lower urinary oestrone (E
methodsWe measured successfully 12 EMs in mid-follicular phase urine samples from 30 CYP3A7*1C carriers and 30 non-carriers using HPLC-MS/MS.
resultsIn addition to having lower urinary E
conclusionsThe CYP3A7*1C allele is associated with a lower urinary E
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Registered trials
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