Evidence map›Paper›PMID 28072722›Full record

SynthesisMedicine2017

Dexmedetomidine prevent postoperative nausea and vomiting on patients during general anesthesia: A PRISMA-compliant meta analysis of randomized controlled trials.

Shenhui Jin, Dong Dong Liang, Chengyu Chen, Minyuan Zhang, Junlu Wang

2 registry-linked trialsAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 50 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06409676 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

Applicability of Enhanced Recovery After Surgery Protocols in the Therapeutic Endoscopy Suite: a Single-Center Randomized Prospective Study

TypeinterventionalSponsorIstituto Clinico HumanitasRan2024 to 2026Enrolled220ConditionsColorectal Endoscopic Submucosal DissectionArmsERAS protocols
NCT07426081 phase3completednot on this mapstarted 2025, after this paper: background citation

Comparison of Dexmedetomidine and Dexamethasone for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Controlled Trial

TypeinterventionalSponsorPatel Hospital, PakistanRan2025 to 2025Enrolled68ConditionsPostoperative Nausea and VomitingArmsDexamedomedine, Dexamethasone
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shenhui JinDepartment of Anesthesiology, The first Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Dong Dong Liang
Chengyu Chen
Minyuan Zhang
Junlu Wang

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative nausea and vomiting (PONV) is a frequent complication in postoperative period. The aim of this article was to evaluate the effect of dexmedetomidine on PONV.

methodRevMan 5.3 software was applied for performing statistic analysis. Twenty-four trials with 2046 patients were included.

resultsThe PONV of the dexmedetomidine group was significantly lower compared with the placebo group (0.56, 95% CI: 0.46, 0.69). Subgroup analysis further confirmed the effect of dexmedetomidine (irrespective of administration mode) (P < 0.00001). Perioperative fentanyl consumption in dexmedetomidine group were also reduced significantly (P < 0.00001). Whereas, side effects such as bradycardia, hypotension increased in dexmedetomidine group (especially in loading dose mode and loading dose plus continuous infusion mode).

conclusionsDexmedetomidine administrated in continuous infusion mode has the advantage to prevent PONV as well as reduce side effects such as bradycardia and hypotension.

Indexed as

Postoperative Nausea and VomitingAnesthesia, GeneralDexmedetomidineHumansHypnotics and SedativesInfusions, IntravenousOutcome and Process Assessment, Health CareRandomized Controlled Trials as TopicSurgical Procedures, OperativeDexmedetomidineHypnotics and Sedatives

Identifiers

PMID28072722
PMCPMC5228682

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.