Observational studyPediatric emergency care2019
Evaluation of the Association of Early Elevated Lactate With Outcomes in Children With Severe Sepsis or Septic Shock.
Observational study in Pediatric emergency care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Criteria for Pediatric Sepsis-A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce.Critical care medicine · 2022Pooled it
- Bioresorbable electrochemical sensors for continuous deep-tissue lactate monitoring in critical care.Nature communications · 2026Article
- Role of biomarkers in pediatric sepsis: What evidence says?World journal of clinical pediatrics · 2026Review
- Association between serum endothelial glycocalyx biomarkers and prognosis in paediatric sepsis.BMC infectious diseases · 2026Observational
- Seeing beyond the numbers: capnography as a vital tool in pediatric emergency care.International journal of emergency medicine · 2026Review
- The role of transcranial Doppler in predicting the incidence and prognosis of sepsis-associated encephalopathy.Intensive care medicine experimental · 2025Article
- Metabolomics of Sepsis and Acute Kidney Injury in Infants and Children: Current Challenges in Prevention, Diagnosis, and Management.Infectious diseases and therapy · 2025Review
- Can Serum Lactate on Admission to Intensive Care Predict Length of Stay? A Retrospective Analysis of Critically Ill Paediatric Oncology Patients.Journal of paediatrics and child health · 2025Observational
- Lactate, an Essential Metabolic Marker in the Diagnosis and Management of Pediatric Conditions.Diagnostics (Basel, Switzerland) · 2025Review
- Article
- Relationship between lactate levels and 28-day mortality in pediatric sepsis: results from the pediatric intensive care database.BMC pediatrics · 2024Article
- Post hospital admission blood lactate measurements are associated with mortality but not neurologic morbidity in children with cerebral malaria.Malaria journal · 2024Article
- Implementing Pediatric Surviving Sepsis Campaign Guidelines: Improving Compliance With Lactate Measurement in the PICU.Critical care explorations · 2023Article
- The evolving value of older biomarkers in the clinical diagnosis of pediatric sepsis.Pediatric research · 2023Review
- A new nomogram for the individualized prediction of children's mortality risk in pediatric intensive care unit.American journal of translational research · 2023Article
- Serum lactate is associated with increased illness severity in immunocompromised pediatric hematology oncology patients presenting to the emergency department with fever.Frontiers in oncology · 2022Article
- Admission serum lactate is associated with all-cause mortality in the pediatric intensive care unit.American journal of translational research · 2022Article
- Improvement of the functioning and efficiency of a Code Blue system after training in a children's hospital in China.Translational pediatrics · 2021Article
- Mean core to peripheral temperature difference and mean lactate levels in first 6 hours of hospitalisation as two indicators of prognosis: an observational cohort study.BMC pediatrics · 2020Observational
- Management of Children With Fever at Risk for Pediatric Sepsis: A Prospective Study in Pediatric Emergency Care.Frontiers in pediatrics · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThe aim of the study was to assess the association of initial lactate (L0) with mortality in children with severe sepsis.
methodsThis prospective cohort study included 74 patients younger than 18 years with severe sepsis admitted to the pediatric intensive care unit (PICU) of a tertiary, academic children's hospital with lactate measured within 3 hours of meeting severe sepsis or septic shock. The primary outcome was in-hospital mortality. The secondary outcomes included PICU and hospital length of stay.
resultsAlthough overall mortality was 10.5% (n = 18), patients with L0 measured (n = 72) had a higher mortality (16% vs 6%, P = 0.03) and higher median PRISM-III risk of mortality scores (P = 0.02) than those who did not. Median L0 was no different between nonsurvivors and survivors (3.6 mmol/L [interquartile range, 2.0-9.0] in nonsurvivors vs 2.3 mmol/L [interquartile range, 1.4-3.5] in survivors, P = 0.11). However, L0 was independently associated with PRISM-III score (coefficient, 1.12; 95% confidence interval, 0.4-1.8; P = 0.003) with an increase in mean PRISM-III score of 1.12 U for every 1 mmol/L increase in L0, with L0 accounting for 12% of the variability in PRISM-III scores between patients. There was no association between L0 and PICU or hospital length of stay.
conclusionsAlthough our single center study did not demonstrate that an elevated early lactate is associated with mortality in pediatric severe sepsis, L0 did correlate strongly with PRISM-III, the most robust measure of mortality risk in pediatrics. Therefore, early lactate measurement may be important as an early biomarker of disease severity. These data should be validated in a larger, multicenter, prospective study.
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