ReviewBiochemistry2017
Arthropod Innate Immune Systems and Vector-Borne Diseases.
Review in Biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Systematic review of innate immune responses againstFrontiers in immunology · 2024Pooled it
- Tick-borne viruses: discovery, clinical aspects, influencing factors and control.Nature reviews. Microbiology · 2026Review
- Partial reconstitution of the prophenoloxidase activation system inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Chromosome-scale genome of Culicoides brevitarsis provides a resource for comparative and vector biology studies.Parasites & vectors · 2026Article
- Clodronate Liposomes Untangle the Role of Hemocytes in <italic>Apis mellifera</italic> Response to Temperature Variation and Microbial Infection.Journal of innate immunity · 2026Article
- Study of Antibiotic Resistance Potential of Spiders Bacteriota and Comparison With the Antibacterial Effect of Essential Oils.MicrobiologyOpen · 2025Article
- Clodronate liposomes untangle the role of hemocytes inbioRxiv : the preprint server for biology · 2025Article
- Hard Ticks as Vectors: The Emerging Threat of Tick-Borne Diseases in India.Pathogens (Basel, Switzerland) · 2024Review
- Immune Reactions of Vector Insects to Parasites and Pathogens.Microorganisms · 2024Review
- Immunomodulatory Peptides as Vaccine Adjuvants and Antimicrobial Agents.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Endogenous Viral Elements in Ixodid Tick Genomes.Viruses · 2023Article
- Article
- Host-pathogen interaction in arthropod vectors: Lessons from viral infections.Frontiers in immunology · 2023Review
- G6PDH as a key immunometabolic and redox trigger in arthropods.Frontiers in physiology · 2023Review
- Purifying selection decreases the potential for Bangui orthobunyavirus outbreaks in humans.Virus evolution · 2023Article
- Vector-virus interaction affects viral loads and co-occurrence.BMC biology · 2022Article
- Impaired immune function accompanies social evolution in spiders.Biology letters · 2022Article
- A balance between vector survival and virus transmission is achieved through JAK/STAT signaling inhibition by a plant virus.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Bacteriota and Antibiotic Resistance in Spiders.Insects · 2022Article
- Infection withViruses · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Arthropods, especially ticks and mosquitoes, are the vectors for a number of parasitic and viral human diseases, including malaria, sleeping sickness, Dengue, and Zika, yet arthropods show tremendous individual variation in their capacity to transmit disease. A key factor in this capacity is the group of genetically encoded immune factors that counteract infection by the pathogen. Arthropod-specific pattern recognition receptors and protease cascades detect and respond to infection. Proteins such as antimicrobial peptides, thioester-containing proteins, and transglutaminases effect responses such as lysis, phagocytosis, melanization, and agglutination. Effector responses are initiated by damage signals such as reactive oxygen species signaling from epithelial cells and recognized by cell surface receptors on hemocytes. Antiviral immunity is primarily mediated by siRNA pathways but coupled with interferon-like signaling, antimicrobial peptides, and thioester-containing proteins. Molecular mechanisms of immunity are closely linked to related traits of longevity and fertility, and arthropods have the capacity for innate immunological memory. Advances in understanding vector immunity can be leveraged to develop novel control strategies for reducing the rate of transmission of both ancient and emerging threats to global health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.