Evidence map›Paper›PMID 28072481›Full record

ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2017

Can Contrast-Enhanced Sonography Detect Bowel Wall Fibrosis in Mixed Inflammatory and Fibrotic Crohn Disease Lesions in an Animal Model?

Jonathan R Dillman, Jonathan M Rubin, Laura A Johnson, David S Moons, Peter D R Higgins

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jonathan R DillmanDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Jonathan M RubinDepartment of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA.
Laura A JohnsonDepartment of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA.
David S MoonsDepartment of Pathology, University of Michigan Health System, Ann Arbor, Michigan, USA.
Peter D R HigginsDepartment of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA.
University of Michigan–Ann Arbor · USCincinnati Children's Hospital Medical Center · USMichigan Medicine · US

Funding

Nonlinear Ultrasound: an Imaging Biomarker of Intestinal Fibrosis in Crohn's DiseaseR01DK109032 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DILLMAN, JONATHAN RUSSELL, HIGGINS, PETER D.R. · 2016 to 2019
$2.4M
NIDDK NIH HHS R01 DK109032
6 · The paper itself

Abstract

objectivesTo determine whether contrast-enhanced sonographic quantitative perfusion parameters can detect bowel wall fibrosis in the setting of mixed inflammatory and fibrotic lesions in a Crohn disease animal model.

methodsThis study was approved by the institutional Committee on the Use and Care of Animals. Multiple (range, 1-5) 2,4,6-trinitrobenzenesulfonic acid-ethanol enemas were used to create intestinal inflammatory lesions with variable fibrosis in female Lewis rats. Low-mechanical index contrast-enhanced sonography was performed 3 days after the final enema using a 0.2-mL bolus of sulfur hexafluoride microbubbles injected through a tail vein. Contrast-enhanced sonographic data were analyzed with software that converts video data into echo-power (linearized) data. Colorectal lesions were scored for histopathologic inflammation and fibrosis; bowel wall collagen was quantified by Western blotting. The Spearman correlation was used to assess associations between contrast-enhanced sonographic quantitative parameters and bowel wall collagen; the Kruskal-Wallis test was used to compare continuous results between histopathologic groups.

resultsThirty-one animals were included in our analysis. Animals were placed into 3 histopathologic cohorts: (1) severe bowel wall inflammation/minimal or no fibrosis (n = 11); (2) severe bowel wall inflammation/moderate fibrosis (n = 9); and (3) severe bowel wall inflammation/severe fibrosis (n = 11). Western blotting showed a significant difference in bowel wall collagen between histopathologic cohorts (P = .0001). There was no correlation between any contrast-enhanced sonographic quantitative parameter and bowel wall collagen (P > .05). There was no difference between histopathologic cohorts for any contrast-enhanced sonographic quantitative parameter (P > .05).

conclusionsContrast-enhanced sonographic quantitative perfusion parameters failed to effectively detect bowel wall fibrosis in the setting of superimposed inflammation in a Crohn disease animal model.

Indexed as

Contrast MediaAnimalsCrohn DiseaseDisease Models, AnimalFemaleFibrosisImage EnhancementInflammationIntestinesRatsRats, Inbred LewReproducibility of ResultsUltrasonographyContrast Mediaanimal modelcontrast-enhanced sonographyCrohn diseasefibrosisgastrointestinal ultrasoundinflammationmicrobubble contrast agent

Identifiers

PMID28072481
PMCPMC6557400
OpenAlexW2571011539

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.