Evidence map›Paper›PMID 28072464›Full record

ArticleBritish journal of pharmacology2017

Genistein and tyrphostin AG556 decrease ultra-rapidly activating delayed rectifier K

Guo-Sheng Xiao, Yan-Hui Zhang, Wei Wu, Hai-Ying Sun, Yan Wang, Gui-Rong Li

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Guo-Sheng XiaoXiamen Cardiovascular Hospital, Xiamen University, Xiamen, Fujian, China.
Yan-Hui ZhangXiamen Cardiovascular Hospital, Xiamen University, Xiamen, Fujian, China.
Wei WuDepartment of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
Hai-Ying SunDepartment of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
Yan WangXiamen Cardiovascular Hospital, Xiamen University, Xiamen, Fujian, China.
Gui-Rong LiXiamen Cardiovascular Hospital, Xiamen University, Xiamen, Fujian, China.ORCID 0000-0002-9437-2280
Xiamen University · CNUniversity of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe ultra-rapidly activating delayed rectifier K EXPERIMENTAL APPROACH: Whole-cell patch voltage clamp technique and immunoprecipitation and Western blotting analysis were used to investigate whether the PTK inhibitors genistein, tyrphostin AG556 (AG556) and PP2 regulate human atrial I KEY

resultsHuman atrial I CONCLUSION AND IMPLICATIONS: The PTK inhibitors genistein and AG556 decrease human atrial I

Indexed as

Cells, CulturedDelayed Rectifier Potassium ChannelsErbB ReceptorsGenisteinHeart AtriaHEK293 CellsHumansProtein Kinase InhibitorsPyrimidinesTyrphostinsAG 1879AG 556Delayed Rectifier Potassium ChannelsEGFR protein, humanErbB ReceptorsGenisteinProtein Kinase InhibitorsPyrimidinesTyrphostins

Identifiers

PMID28072464
PMCPMC5323513
OpenAlexW2570336717

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.