ArticleTranslational psychiatry2017
Functional neuroimaging effects of recently discovered genetic risk loci for schizophrenia and polygenic risk profile in five RDoC subdomains.
Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Linking Polygenic Risk of Schizophrenia to Variation in Magnetic Resonance Imaging Brain Measures: A Comprehensive Systematic Review.Schizophrenia bulletin · 2024Pooled it
- A systematic review of associations between functional MRI activity and polygenic risk for schizophrenia and bipolar disorder.Brain imaging and behavior · 2019Pooled it
- Polygenic risk has an impact on the structural plasticity of hippocampal subfields during aerobic exercise combined with cognitive remediation in multi-episode schizophrenia.Translational psychiatry · 2017Trial
- Neural mechanisms underlying reward processing and social cognition: A replication study with a Japanese sample.PloS one · 2025Article
- Altered cortical synaptic lipid signaling leads to intermediate phenotypes of mental disorders.Molecular psychiatry · 2024Article
- Episodic Memory and Schizophrenia: From Characterization of Relational Memory Impairments to Neuroimaging Biomarkers.Current topics in behavioral neurosciences · 2023Article
- Bringing machine learning to research on intellectual and developmental disabilities: taking inspiration from neurological diseases.Journal of neurodevelopmental disorders · 2022Review
- A pan-tissue DNA methylation atlas enables in silico decomposition of human tissue methylomes at cell-type resolution.Nature methods · 2022Article
- Clinical translational neuroimaging of the antioxidant effect of N-acetylcysteine on neural microstructure.Magnetic resonance in medicine · 2022Article
- Advancing translational research in neuroscience through multi-task learning.Frontiers in psychiatry · 2022Review
- [Twelve years of research domain criteria in psychiatric research and practice: claim and reality].Der Nervenarzt · 2021Review
- Transcriptome Sequencing Reveals the Potential Mechanisms of Modified Electroconvulsive Therapy in Schizophrenia.Psychiatry investigation · 2021Article
- Do ADHD-impulsivity and BMI have shared polygenic and neural correlates?Molecular psychiatry · 2021Article
- Association of a Reproducible Epigenetic Risk Profile for Schizophrenia With Brain Methylation and Function.JAMA psychiatry · 2020Article
- Social Cognition in a Research Domain Criteria Perspective: A Bridge Between Schizophrenia and Autism Spectra Disorders.Frontiers in psychiatry · 2020Review
- Building a schizophrenia genetic network: transcription factor 4 regulates genes involved in neuronal development and schizophrenia risk.Human molecular genetics · 2018Article
- The cAMP responsive element-binding (CREB)-1 gene increases risk of major psychiatric disorders.Molecular psychiatry · 2018Article
- Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences.Annual review of clinical psychology · 2018Review
- Schizophrenia polygenic risk score predicts mnemonic hippocampal activity.Brain : a journal of neurology · 2018Article
- Mapping the Schizophrenia Genes by Neuroimaging: The Opportunities and the Challenges.International journal of molecular sciences · 2018Review
Corrections and comments
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, 125 loci with genome-wide support for association with schizophrenia were identified. We investigated the impact of these variants and their accumulated genetic risk on brain activation in five neurocognitive domains of the Research Domain Criteria (working memory, reward processing, episodic memory, social cognition and emotion processing). In 578 healthy subjects we tested for association (i) of a polygenic risk profile score (RPS) including all single-nucleotide polymorphisms (SNPs) reaching genome-wide significance in the recent genome-wide association studies (GWAS) meta-analysis and (ii) of all independent genome-wide significant loci separately that showed sufficient distribution of all allelic groups in our sample (105 SNPs). The RPS was nominally associated with perigenual anterior cingulate and posterior cingulate/precuneus activation during episodic memory (P
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.