ArticleNature communications2017
Agrp neuron activity is required for alcohol-induced overeating.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Ethanol ingestion via frugivory in wild chimpanzees.Science advances · 2025Article
- Precision medicine for obesity: current evidence and insights for personalization of obesity pharmacotherapy.International journal of obesity (2005) · 2025Review
- Human Evolution and Dietary Ethanol.Nutrients · 2021Review
- Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity.Molecular psychiatry · 2021Article
- Association between alcohol consumption status and obesity-related comorbidities in men: data from the 2016 Korean community health survey.BMC public health · 2021Article
- Neuronal modulation of hepatic lipid accumulation induced by bingelike drinking.American journal of physiology. Endocrinology and metabolism · 2020Article
- High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons ineLife · 2020Article
- Manipulations of Central Amygdala Neurotensin Neurons Alter the Consumption of Ethanol and Sweet Fluids in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Natural and Drug Rewards Engage Distinct Pathways that Converge on Coordinated Hypothalamic and Reward Circuits.Neuron · 2019Article
- The use of chemogenetic approaches in alcohol use disorder research and treatment.Alcohol (Fayetteville, N.Y.) · 2019Review
- Ethanol facilitates socially evoked memory recall in mice by recruiting pain-sensitive anterior cingulate cortical neurons.Nature communications · 2018Article
- Pharmacological interventions for obesity: current and future targets.Current addiction reports · 2018Article
- Chemogenetic Tools for Causal Cellular and Neuronal Biology.Physiological reviews · 2018Review
- Physiology: How alcohol ramps up hunger signals.Nature · 2017Article
- Nucleus Accumbens MC4-R Stimulation Reduces Food and Ethanol Intake in Adult Rats Regardless of Binge-Like Ethanol Exposure during Adolescence.Frontiers in behavioral neuroscience · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Alcohol intake associates with overeating in humans. This overeating is a clinical concern, but its causes are puzzling, because alcohol (ethanol) is a calorie-dense nutrient, and calorie intake usually suppresses brain appetite signals. The biological factors necessary for ethanol-induced overeating remain unclear, and societal causes have been proposed. Here we show that core elements of the brain's feeding circuits-the hypothalamic Agrp neurons that are normally activated by starvation and evoke intense hunger-display electrical and biochemical hyperactivity on exposure to dietary doses of ethanol in brain slices. Furthermore, by circuit-specific chemogenetic interference in vivo, we find that the Agrp cell activity is essential for ethanol-induced overeating in the absence of societal factors, in single-housed mice. These data reveal how a widely consumed nutrient can paradoxically sustain brain starvation signals, and identify a biological factor required for appetite evoked by alcohol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.