Evidence map›Paper›PMID 28072387›Full record

ArticleeLife2017

Embryonic origin of adult stem cells required for tissue homeostasis and regeneration.

Erin L Davies, Kai Lei, Christopher W Seidel, Amanda E Kroesen, Sean A McKinney, Longhua Guo, Sofia Mc Robb, Eric J Ross, Kirsten Gotting, Alejandro Sánchez Alvarado

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 93 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. eLife · 2025
    Article
  6. bioRxiv : the preprint server for biology · 2025
    Article
  7. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Ex vivo functional whole organ in biomedical research: a review.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025
    Review
  12. Mammalian Blastema: Possibility and Potentials.International journal of stem cells · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Annelids as models of germ cell and gonad regeneration.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Erin L DaviesHoward Hughes Medical Institute, Stowers Institute for Medical Research, Kansas City, United States.
Kai LeiHoward Hughes Medical Institute, Stowers Institute for Medical Research, Kansas City, United States.
Christopher W SeidelHoward Hughes Medical Institute, Stowers Institute for Medical Research, Kansas City, United States.
Amanda E KroesenHoward Hughes Medical Institute, Stowers Institute for Medical Research, Kansas City, United States.
Sean A McKinneyHoward Hughes Medical Institute, Stowers Institute for Medical Research, Kansas City, United States.
Longhua GuoHoward Hughes Medical Institute, Stowers Institute for Medical Research, Kansas City, United States.
Sofia Mc RobbHoward Hughes Medical Institute, Stowers Institute for Medical Research, Kansas City, United States.
Eric J RossHoward Hughes Medical Institute, Stowers Institute for Medical Research, Kansas City, United States.
Kirsten GottingHoward Hughes Medical Institute, Stowers Institute for Medical Research, Kansas City, United States.
Alejandro Sánchez AlvaradoHoward Hughes Medical Institute, Stowers Institute for Medical Research, Kansas City, United States.ORCID 0000-0002-1966-6959
Stowers Institute for Medical Research · US

Funding

The molecular basis of planarian regenerationR37GM057260 · NIGMS · UNIVERSITY OF UTAH · PI SANCHEZ ALVARADO, ALEJANDRO · 2009 to 2018
$2.8M
The molecular basis of planarian regenerationR01GM057260 · NIGMS · UNIVERSITY OF UTAH · PI SANCHEZ ALVARADO, ALEJANDRO · 1998 to 2006
$1.7M
Howard Hughes Medical InstituteNIGMS NIH HHS R37 GM057260
6 · The paper itself

Abstract

Planarian neoblasts are pluripotent, adult somatic stem cells and lineage-primed progenitors that are required for the production and maintenance of all differentiated cell types, including the germline. Neoblasts, originally defined as undifferentiated cells residing in the adult parenchyma, are frequently compared to embryonic stem cells yet their developmental origin remains obscure. We investigated the provenance of neoblasts during

Indexed as

HomeostasisRegenerationAdult Stem CellsAnimalsCell LineagePlanariansanarchic cleavagedevelopmental biologyembryogenesisplanariaSchmidtea mediterraneastem cells

Identifiers

PMID28072387
PMCPMC5293490
OpenAlexW2568239413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.