ArticleAging & mental health2018
Anxiety symptoms and risk of dementia and mild cognitive impairment in the oldest old women.
Article in Aging & mental health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Support for midlife anxiety diagnosis as an independent risk factor for dementia: a systematic review.BMJ open · 2018Pooled it
- Mild Behavioral Impairment: A Population-Based Study.The Journal of neuropsychiatry and clinical neurosciences · 2026Article
- Neurocognitive disparities: investigating ethnicity and mental health in rural aging adults.Aging · 2024Article
- Effects of Future Subjective Expectations on Cognitive Decline and Dementia among Middle-Aged and Older Adults.Behavioral sciences (Basel, Switzerland) · 2024Article
- Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety.Translational psychiatry · 2024Article
- Association of Anxiety and Unspecified Emotional Distress Obtained from a Medical Records Linkage System with Incident Cognitive Outcomes in a Population-Based Setting.Journal of Alzheimer's disease : JAD · 2024Article
- Contributions of loneliness to cognitive impairment and dementia in older adults are independent of other risk factors and Alzheimer's pathology: a narrative review.Frontiers in human neuroscience · 2024Review
- Interactions Between Neuropsychiatric Symptoms and Alzheimer's Disease Neuroimaging Biomarkers in Predicting Longitudinal Cognitive Decline.Psychiatric research and clinical practice · 2023Article
- Association of Cerebrovascular Imaging Biomarkers, Depression, and Anxiety, with Mild Cognitive Impairment.Journal of Alzheimer's disease reports · 2023Article
- Adjustment of the MIND diet tool for discriminating Greek patients with dementia: A confirmatory factor analysis.Frontiers in neurology · 2022Article
- Neuropsychiatric symptoms and the outcome of cognitive trajectories in older adults free of dementia: The Mayo Clinic Study of Aging.International journal of geriatric psychiatry · 2021Article
- Does Anxiety Increase the Risk of All-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies.Journal of clinical medicine · 2020Review
- Physical multimorbidity and subjective cognitive complaints among adults in the United Kingdom: a cross-sectional community-based study.Scientific reports · 2019Article
- Anxiety and 10-Year Risk of Incident Dementia-An Association Shaped by Depressive Symptoms: Results of the Prospective Three-City Study.Frontiers in neuroscience · 2018Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesResearch is limited and findings conflict regarding anxiety as a predictor of future cognitive decline in the oldest old persons. We examined the relationship between levels of and changes in anxiety symptoms, and subsequent dementia and mild cognitive impairment (MCI) in the oldest old women.
methodWe conducted secondary analyses of data collected from 1425 community-dwelling women (mean age = 82.8, SD ±3.1 years) followed on average for five years. The Goldberg Anxiety Scale was used to assess anxiety symptoms at baseline, and an expert clinical panel adjudicated dementia and MCI at follow-up. Participants with probable cognitive impairment at baseline were excluded.
resultsAt baseline, 190 (13%) women had moderate/severe anxiety symptoms and 403 (28%) had mild anxiety symptoms. Compared with those with no anxiety symptoms at baseline, women with mild anxiety symptoms were more likely to develop dementia at follow-up (multivariable-adjusted odds ratio = 1.66, 95% confidence interval 1.12-2.45). No significant association was observed between anxiety symptoms and MCI.
conclusionIn the oldest old women, our findings suggest that mild anxiety symptoms may predict future risk of dementia, but not MCI. Future studies should explore potential biological mechanisms underlying associations of anxiety with cognitive impairment.
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Registered trials
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