SynthesisJournal of clinical hypertension (Greenwich, Conn.)2017
Risk of hypertensive disorders in pregnancy following assisted reproductive technology: overview and meta-analysis.
Synthesis in Journal of clinical hypertension (Greenwich, Conn.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Assisted reproductive technology and hypertensive disorders of pregnancy: systematic review and meta-analyses.BMC pregnancy and childbirth · 2021Pooled it
- Assisted reproductive technology and the risk of preeclampsia: an updated systematic review and meta-analysis.BMC pregnancy and childbirth · 2019Pooled it
- Risk of hypertensive disorders in pregnancy following assisted reproductive technology: overview and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2017Pooled it
- Secular trends in the prevalence of low birthweight infants in Japan from 1980 to 2020: a joinpoint regression analysis.Nagoya journal of medical science · 2026Article
- Human placentation: foundations and implications for reproductive endocrinology and infertility.Systems biology in reproductive medicine · 2025Review
- Association between embryo transfer season and the risks of hypertensive disorders of pregnancy and gestational diabetes mellitus.Journal of assisted reproduction and genetics · 2025Article
- Preeclampsia Management and Maternal Ophthalmic Artery Doppler Measurements between 19 and 23 Weeks of Gestation.Journal of clinical medicine · 2024Article
- Perinatal complications and neonatal outcomes inFrontiers in endocrinology · 2024Article
- Comparing the occurrence rate of gestational hypertension during pregnancy with frozen embryo transfer and natural pregnancy.Journal of family medicine and primary care · 2023Article
- Pregnancy by Oocyte Donation: Reviewing Fetal-Maternal Risks and Complications.International journal of molecular sciences · 2023Review
- Pregnancy outcomes and disease phenotype of hypertensive disorders of pregnancy in singleton pregnancies after in vitro fertilization: a retrospective analysis of 1130 cases.BMC pregnancy and childbirth · 2023Article
- Hypertension in Pregnancy: A Diagnostic and Therapeutic Overview.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2023Review
- Mediation effect of pregnancy-induced hypertension on the association between assisted reproductive technology and adverse neonatal outcomes: a population-based study.BMC pregnancy and childbirth · 2023Article
- Even high normal blood pressure affects live birth rate in women undergoing fresh embryo transfer.Human reproduction (Oxford, England) · 2022Observational
- Sex differences in hypertension. Do we need a sex-specific guideline?Frontiers in cardiovascular medicine · 2022Review
- Maternal-Perinatal Variables in Patients with Severe Preeclampsia Who Develop Acute Kidney Injury.Journal of clinical medicine · 2021Article
- Hypertension in Women Across the Lifespan.Current atherosclerosis reports · 2021Review
- Temporal Trends in Pregnancy-Associated Stroke and Its Outcomes Among Women With Hypertensive Disorders of Pregnancy.Journal of the American Heart Association · 2020Article
- Assisted reproductive technologies induce temporally specific placental defects and the preeclampsia risk marker sFLT1 in mouse.Development (Cambridge, England) · 2020Article
- Hypertension and Reproduction.Current hypertension reports · 2020Review
Corrections and comments
- Commented on by
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extent of the increased risk of pregnancy hypertensive disorders following assisted reproductive technology (ART) was investigated. PubMed and the Cochrane Collaboration Library were used as data sources to identify and select longitudinal cohorts comparing pregnancies following ART with spontaneously conceived pregnancies, between 1978 and June 2016. Risk ratios and 95% confidence intervals (CIs) of three outcomes, ie, gestational hypertension (GH), preeclampsia (PE), and their sum (PHD), were calculated. Stratification of results by gestation order (singletons and nonsingletons) was pursued, but a separate "all orders" mixed stratification was considered. Sixty-six longitudinal studies (7 038 029 pregnancies; 203 375 following any ART) were eligible. All outcomes independent of gestation order ("all orders") were increased following any invasive ART: GH (+79% [95% CI, 24%-157%]) and PE (+75% [95% CI, 50%-103%]) to a greater extent, with smaller increases in PHD (+54% [95% CI, 39%-70%]). The risk of PHD following ART steadily increased independent of gestation order.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.