Evidence map›Paper›PMID 28071848›Full record

ArticleAngewandte Chemie (International ed. in English)2017

GXXXG-Mediated Parallel and Antiparallel Dimerization of Transmembrane Helices and Its Inhibition by Cholesterol: Single-Pair FRET and 2D IR Studies.

Yoshiaki Yano, Kotaro Kondo, Yuta Watanabe, Tianqi O Zhang, Jia-Jung Ho, Shinya Oishi, Nobutaka Fujii, Martin T Zanni, Katsumi Matsuzaki

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Mechanosensitive aquaporins.Biophysical reviews · 2023
    Review
  2. Review
  3. Article
  4. Fast slow folding of an outer membrane porin.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  5. Article
  6. Review
  7. Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yoshiaki YanoGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606-8501, Japan.
Kotaro KondoGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606-8501, Japan.
Yuta WatanabeGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606-8501, Japan.
Tianqi O ZhangDepartment of Chemistry, University of Wisconsin, Madison, WI, 53706, USA.
Jia-Jung HoDepartment of Chemistry, University of Wisconsin, Madison, WI, 53706, USA.
Shinya OishiGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606-8501, Japan.
Nobutaka FujiiGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606-8501, Japan.
Martin T ZanniDepartment of Chemistry, University of Wisconsin, Madison, WI, 53706, USA.
Katsumi MatsuzakiGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606-8501, Japan.
Kyoto Pharmaceutical University · JPUniversity of Wisconsin–Madison · USKyoto University · JP

Funding

Structural mechanism of diabetic amyloid formationR01DK079895 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Martin T Zanni · 2008 to 2026
$7.7M
Crystallin aggregation and stabilizationR01GM102387 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI ZANNI, MARTIN T · 2014 to 2017
$1.1M
NIDDK NIH HHS R01 DK079895NIGMS NIH HHS R01 GM102387
6 · The paper itself

Abstract

Small-residue-mediated interhelical packings are ubiquitously found in helical membrane proteins, although their interaction dynamics and lipid dependence remain mostly uncharacterized. We used a single-pair FRET technique to examine the effect of a GXXXG motif on the association of de novo designed (AALALAA)

Indexed as

Amino Acid SequenceCholesterolFluorescence Resonance Energy TransferLiposomesPeptidesProtein MultimerizationProtein Structure, SecondarySpectrophotometry, InfraredCholesterolLiposomesPeptidesFRETGXXXG motifIR spectroscopymembrane proteinssingle-molecule studies

Identifiers

PMID28071848
PMCPMC5507574
OpenAlexW2568613405

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.