ArticleScientific reports2017
Far-infrared protects vascular endothelial cells from advanced glycation end products-induced injury via PLZF-mediated autophagy in diabetic mice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Endothelial ZBTB16: a molecular shield against cardiac aging.European heart journal · 2026Article
- Therapeutic Potential of Infrared and Related Light Therapies in Metabolic Diseases.International journal of molecular sciences · 2025Review
- Enhancement of the transfection efficiency of porcine spermatogonial stem cells by far-infrared radiation-based electroporation.In vitro cellular & developmental biology. Animal · 2024Article
- The Impact of DAZZEON αSleepClocks & sleep · 2024Article
- ZBTB16 eases lipopolysaccharide‑elicited inflammation, apoptosis and degradation of extracellular matrix in chondrocytes during osteoarthritis by suppressing GRK2 transcription.Experimental and therapeutic medicine · 2023Article
- Endothelial Autophagy Dysregulation in Diabetes.Cells · 2023Review
- Physiological and pathological characteristics of vascular endothelial injury in diabetes and the regulatory mechanism of autophagy.Frontiers in endocrinology · 2023Review
- Far-infrared radiation alleviates cisplatin-induced vascular damage and impaired circulation via activation of HIF-1α.Cancer science · 2022Article
- Suppressive role of E3 ubiquitin ligase FBW7 in type I diabetes in non-obese diabetic mice through mediation of ubiquitination of EZH2.Cell death discovery · 2021Article
- Article
- miR-548aq-3p is a novel target of Far infrared radiation which predicts coronary artery disease endothelial colony forming cell responsiveness.Scientific reports · 2020Article
- Inhibition of autophagy of Cajal mesenchymal cells by gavage of tong bian decoction based on the rat model of chronic transit constipation.Saudi journal of biological sciences · 2020Article
- Detecting the limits of the biological effects of far-infrared radiation on epithelial cells.Scientific reports · 2019Article
- Far-infrared Radiation Improves Motor Dysfunction and Neuropathology in Spinocerebellar Ataxia Type 3 Mice.Cerebellum (London, England) · 2019Article
- Far-infrared Ray-mediated Antioxidant Potentials are Important for Attenuating Psychotoxic Disorders.Current neuropharmacology · 2019Review
- Far infrared promotes wound healing through activation of Notch1 signaling.Journal of molecular medicine (Berlin, Germany) · 2017Article
- Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice.PloS one · 2017Article
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Authors and funding
13 authors at 5 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The accumulation of advanced glycation end products (AGEs) in diabetic patients induces vascular endothelial injury. Promyelocytic leukemia zinc finger protein (PLZF) is a transcription factor that can be activated by low-temperature far-infrared (FIR) irradiation to exert beneficial effects on the vascular endothelium. In the present study, we investigated the influence of FIR-induced PLZF activation on AGE-induced endothelial injury both in vitro and in vivo. FIR irradiation inhibited AGE-induced apoptosis in human umbilical vein endothelial cells (HUVECs). PLZF activation increased the expression of phosphatidylinositol-3 kinases (PI3K), which are important kinases in the autophagic signaling pathway. FIR-induced PLZF activation led to autophagy in HUVEC, which was mediated through the upregulation of PI3K. Immunofluorescence staining showed that AGEs were engulfed by HUVECs and localized to lysosomes. FIR-induced autophagy promoted AGEs degradation in HUVECs. In nicotinamide/streptozotocin-induced diabetic mice, FIR therapy reduced serum AGEs and AGEs deposition at the vascular endothelium. FIR therapy also reduced diabetes-induced inflammatory markers in the vascular endothelium and improved vascular endothelial function. These protective effects of FIR therapy were not found in PLZF-knockout mice. Our data suggest that FIR-induced PLZF activation in vascular endothelial cells protects the vascular endothelium in diabetic mice from AGE-induced injury.
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