Evidence map›Paper›PMID 28071753›Full record

ArticleScientific reports2017

De novo assembly, annotation, and characterization of the whole brain transcriptome of male and female Syrian hamsters.

Katharine E McCann, David M Sinkiewicz, Alisa Norvelle, Kim L Huhman

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Genes · 2026
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  5. CRISPR-Cas9 editing of the arginine-vasopressin V1a receptor produces paradoxical changes in social behavior in Syrian hamsters.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katharine E McCannNeuroscience Institute Georgia State University, 161 Jesse Hill Jr. Drive Atlanta, Georgia 30303, USA.
David M SinkiewiczNeuroscience Institute Georgia State University, 161 Jesse Hill Jr. Drive Atlanta, Georgia 30303, USA.
Alisa NorvelleNeuroscience Institute Georgia State University, 161 Jesse Hill Jr. Drive Atlanta, Georgia 30303, USA.
Kim L HuhmanNeuroscience Institute Georgia State University, 161 Jesse Hill Jr. Drive Atlanta, Georgia 30303, USA.

Funding

Neurobiology of Social BehaviorR01MH062044 · NIMH · GEORGIA STATE UNIVERSITY · PI HUHMAN, KIM L · 2002 to 2017
$4.5M
NIMH NIH HHS R01 MH062044
6 · The paper itself

Abstract

Hamsters are an ideal animal model for a variety of biomedical research areas such as cancer, virology, circadian rhythms, and behavioural neuroscience. The use of hamsters has declined, however, most likely due to the dearth of genetic tools available for these animals. Our laboratory uses hamsters to study acute social stress, and we are beginning to investigate the genetic mechanisms subserving defeat-induced behavioural change. We have been limited, however, by the lack of genetic resources available for hamsters. In this study, we sequenced the brain transcriptome of male and female Syrian hamsters to generate the necessary resources to continue our research. We completed a de novo assembly and after assembly optimization, there were 113,329 transcripts representing 14,530 unique genes. This study is the first to characterize transcript expression in both female and male hamster brains and offers invaluable information to promote understanding of a host of important biomedical research questions for which hamsters are an excellent model.

Indexed as

Molecular Sequence AnnotationAnimalsBrainCricetinaeFemaleGene Expression ProfilingGene Expression RegulationGene OntologyMaleMesocricetusRNA, MessengerSequence Analysis, RNATranscriptomeRNA, Messenger

Identifiers

PMID28071753
PMCPMC5223125

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.