ArticleScientific reports2017
In-silico experiments of zebrafish behaviour: modeling swimming in three dimensions.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- A Human Glucoregulatory Model for the Rational Design and Evaluation of Diabetes Therapeutics.ACS pharmacology & translational science · 2026Article
- Mathematical modeling of zebrafish social behavior in response to acute caffeine administration.Frontiers in applied mathematics and statistics · 2021Article
- Modeling multi-sensory feedback control of zebrafish in a flow.PLoS computational biology · 2021Article
- Model-based feedback control of live zebrafish behavior via interaction with a robotic replica.IEEE transactions on robotics : a publication of the IEEE Robotics and Automation Society · 2020Article
- The zebrafish subcortical social brain as a model for studying social behavior disorders.Disease models & mechanisms · 2019Review
- A Comparison of Individual Learning and Social Learning in Zebrafish Through an Ethorobotics Approach.Frontiers in robotics and AI · 2019Article
- Detecting intermittent switching leadership in coupled dynamical systems.Scientific reports · 2018Article
- A new paradigm in modelling the evolution of a stand via the distribution of tree sizes.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zebrafish is fast becoming a species of choice in biomedical research for the investigation of functional and dysfunctional processes coupled with their genetic and pharmacological modulation. As with mammals, experimentation with zebrafish constitutes a complicated ethical issue that calls for the exploration of alternative testing methods to reduce the number of subjects, refine experimental designs, and replace live animals. Inspired by the demonstrated advantages of computational studies in other life science domains, we establish an authentic data-driven modelling framework to simulate zebrafish swimming in three dimensions. The model encapsulates burst-and-coast swimming style, speed modulation, and wall interaction, laying the foundations for in-silico experiments of zebrafish behaviour. Through computational studies, we demonstrate the ability of the model to replicate common ethological observables such as speed and spatial preference, and anticipate experimental observations on the correlation between tank dimensions on zebrafish behaviour. Reaching to other experimental paradigms, our framework is expected to contribute to a reduction in animal use and suffering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.