ArticleScientific reports2017
spict, a cyst cell-specific gene, regulates starvation-induced spermatogonial cell death in the Drosophila testis.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Stem cell competition.Current topics in developmental biology · 2026Review
- Cyst stem cell lineage GAL4 transgenes are robustly expressed in hub cells of themicroPublication biology · 2026Article
- Oral intake of aripiprazole compromises male fertility in Drosophila.Biology direct · 2025Article
- Interplay of EGFR, JNK, and ROS signaling in soma-germline communication in the Drosophila testis.Stem cell reports · 2025Article
- Signals from the niche promote distinct modes of translation initiation to control stem cell differentiation and renewal in the Drosophila testis.PLoS biology · 2025Article
- Sacrificing cells of the cyst: non-apoptotic cell death in germline cysts via acidification.Frontiers in cell death · 2025Article
- Licensing and niche competition in spermatogenesis: mathematical models suggest complementary regulation of tissue maintenance.Development (Cambridge, England) · 2025Article
- Transsynaptic BMP Signaling Regulates Fine-Scale Topography between Adjacent Sensory Neurons.eNeuro · 2024Article
- A meiotic switch in lysosome activity supports spermatocyte development in young flies but collapses with age.iScience · 2022Article
- The phagocytic cyst cells inScience advances · 2022Article
- Germ cells commit somatic stem cells to differentiation following priming by PI3K/Tor activity in the Drosophila testis.PLoS genetics · 2021Article
- Article
- Cyclin E and Cdk1 regulate the termination of germline transit-amplification process inCell cycle (Georgetown, Tex.) · 2020Article
- Regulation of Drosophila germline stem cells.Current opinion in cell biology · 2019Review
- Review
- Somatic support cells regulate germ cell survival through the Baz/aPKC/Par6 complex.Development (Cambridge, England) · 2019Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Tissues are maintained in a homeostatic state by balancing the constant loss of old cells with the continued production of new cells. Tissue homeostasis can shift between high and low turnover states to cope with environmental changes such as nutrient availability. Recently, we discovered that the elimination of transit-amplifying cells plays a critical role in maintaining the stem cell population during protein starvation in the Drosophila testis. Here, we identify spict, a gene expressed specifically in differentiating cyst cells, as a regulator of spermatogonial death. Spict is upregulated in cyst cells that phagocytose dying spermatogonia. We propose that phagocytosis and subsequent clearance of dead spermatogonia, which is partly promoted by Spict, contribute to stem cell maintenance during prolonged protein starvation.
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