ArticleScientific reports2017
Assessment of phospholipid synthesis related biomarkers for perinatal asphyxia: a piglet study.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- Searching molecular biomarkers correlating with BSID-III at 24 months in infants with neonatal hypoxic-ischemic encephalopathy.European journal of pediatrics · 2024Article
- Blood Plasma Metabolic Profile of Newborns with Hypoxic-Ischaemic Encephalopathy by GC-MS.BioMed research international · 2021Article
- A Metabolomic Approach in Search of Neurobiomarkers of Perinatal Asphyxia: A Review of the Current Literature.Frontiers in pediatrics · 2021Review
- Exploring Perinatal Asphyxia by Metabolomics.Metabolites · 2020Review
- Association between newborn screening analytes and hypoxic ischemic encephalopathy.Scientific reports · 2019Article
- Multiple-Omics Techniques Reveal the Role of Glycerophospholipid Metabolic Pathway in the Response ofFrontiers in microbiology · 2019Article
- Oxidative Stress in the Newborn Period: Useful Biomarkers in the Clinical Setting.Antioxidants (Basel, Switzerland) · 2018Review
- Blood biomarkers for evaluation of perinatal encephalopathy: state of the art.Current opinion in pediatrics · 2018Review
- Plasma metabolite score correlates with Hypoxia time in a newly born piglet model for asphyxia.Redox biology · 2017Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prompt and reliable identification of infants at risk of hypoxic-ischemic encephalopathy secondary to perinatal asphyxia in the first critical hours is important for clinical decision-making and yet still remains a challenge. This work strives for the evaluation of a panel of metabolic biomarkers that have been associated with the hypoxic-ischemic insult in the perinatal period. Plasma and urine samples from a consolidated newborn piglet model of hypoxia and withdrawn before and at different time points after a hypoxic insult were analyzed and compared to a control group. Time-dependent metabolic biomarker profiles were studied and observed patterns were similar to those of lactate levels, which are currently considered the gold standard for assessing hypoxia. Class prediction performance could be improved by the use of a combination of the whole panel of determined metabolites in plasma as compared to lactate values. Using a multivariate model including lactate together with the studied metabolic biomarkers allowed to improve the prediction performance of duration of hypoxia time, which correlates with the degree of brain damage. The present study evidences the usefulness of choline and related metabolites for improving the early assessment of the severity of the hypoxic insult.
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