Early life peripheral lipopolysaccharide challenge reprograms catecholaminergic neurons.

Lin Kooi Ong, Erin A Fuller, Luba Sominsky, Deborah M Hodgson, Peter R Dunkley, Phillip W Dickson

Open access · goldAbstract read

In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.5field-weighted citation impact, top 31% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

Gut Microbiota and the Neuroendocrine System.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lin Kooi OngSchool of Biomedical Sciences and Pharmacy and Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW 2308, Australia.

Erin A FullerLaboratory of Neuroimmunology, School of Psychology and Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW 2308, Australia.

Luba SominskyLaboratory of Neuroimmunology, School of Psychology and Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW 2308, Australia.

Deborah M HodgsonLaboratory of Neuroimmunology, School of Psychology and Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW 2308, Australia.

Peter R DunkleySchool of Biomedical Sciences and Pharmacy and Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW 2308, Australia.

Phillip W DicksonSchool of Biomedical Sciences and Pharmacy and Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW 2308, Australia.

Hunter Medical Research Institute · AUUniversity of Newcastle Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal immune challenge with the bacterial mimetic lipopolysaccharide has the capacity to generate long-term changes in the brain. Neonatal rats were intraperitoneally injected with lipopolysaccharide (0.05 mg/kg) on postnatal day (PND) 3 and again on PND 5. The activation state of tyrosine hydroxylase (TH) was measured in the locus coeruleus, ventral tegmental area and substantia nigra on PND 85. In the locus coeruleus there was an approximately four-fold increase in TH activity. This was accompanied by a significant increase in TH protein together with increased phosphorylation of all three serine residues in the N-terminal region of TH. In the ventral tegmental area, a significant increase in TH activity and increased phosphorylation of the serine 40 residue was seen. Neonatal lipopolysaccharide had no effect on TH activation in the substantia nigra. These results indicate the capacity of a neonatal immune challenge to generate long-term changes in the activation state of TH, in particular in the locus coeruleus. Overall, the current results demonstrate the enduring outcomes of a neonatal immune challenge on specific brain catecholaminergic regions associated with catecholamine synthesis. This highlights a novel mechanism for long-term physiological and behavioural alterations induced by this model.

Indexed as

AnimalsAnimals, NewbornCalcium-Binding ProteinsCatecholaminesGlial Fibrillary Acidic ProteinLipopolysaccharidesLocus CoeruleusMicrofilament ProteinsNeuronsPhosphorylationRats, WistarSubstantia NigraTyrosine 3-MonooxygenaseVentral Tegmental AreaAif1 protein, ratCalcium-Binding ProteinsCatecholaminesGlial Fibrillary Acidic ProteinLipopolysaccharidesMicrofilament ProteinsTyrosine 3-Monooxygenase

Identifiers

PMID28071709

DOI10.1038/srep40475

PMCPMC5223129

OpenAlexW2569040951

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.