Evidence map›Paper›PMID 28070798›Full record

ReviewReviews in endocrine & metabolic disorders2017

Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept.

Barbara Altieri, Giovanna Muscogiuri, Luigi Barrea, Chantal Mathieu, Carla V Vallone, Luca Mascitelli, Giorgia Bizzaro, Vincenzo M Altieri, Giacomo Tirabassi, Giancarlo Balercia and 6 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Reviews in endocrine & metabolic disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 8 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 8 syntheses or guidelines pooled it, 182 citations in OpenAlex.

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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 3 countries.

Barbara AltieriDivision of Endocrinology and Metabolic Diseases, Institute of Medical Pathology, Catholic University of the Sacred Heart, Rome, Italy. altieri.barbara@gmail.com.
Giovanna MuscogiuriIos and Coleman Medicina Futura Medical Center, University Federico II, Naples, Italy.
Luigi BarreaIos and Coleman Medicina Futura Medical Center, University Federico II, Naples, Italy.
Chantal MathieuClinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
Carla V ValloneEmergency Department, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy.
Luca MascitelliComando Brigata Alpina Julia/Multinational Land Force, Medical Service, Udine, Italy.
Giorgia BizzaroTSEM med Swiss SA, Lugano, Switzerland.
Vincenzo M AltieriDepartment of Urology, Bolognini Hospital, Seriate, Italy.
Giacomo TirabassiDivision of Endocrinology, Department of Clinical and Molecular Sciences, Umberto I Hospital, Polytechnic University of Marche, Ancona, Italy.
Giancarlo BalerciaDivision of Endocrinology, Department of Clinical and Molecular Sciences, Umberto I Hospital, Polytechnic University of Marche, Ancona, Italy.
Silvia SavastanoDepartment of Clinical Medicine and Surgery, University "Federico II", Naples, Italy.
Nicola BizzaroLaboratory of Clinical Pathology, San Antonio Hospital, Tolmezzo, Italy.
Cristina L RonchiDivision of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital of Wuerzburg, Wuerzburg, Germany.
Annamaria ColaoDepartment of Clinical Medicine and Surgery, University "Federico II", Naples, Italy.
Alfredo PontecorviDivision of Endocrinology and Metabolic Diseases, Institute of Medical Pathology, Catholic University of the Sacred Heart, Rome, Italy.
Silvia Della CasaDivision of Endocrinology and Metabolic Diseases, Institute of Medical Pathology, Catholic University of the Sacred Heart, Rome, Italy.
Federico II University Hospital · ITUniversità Cattolica del Sacro Cuore · ITMarche Polytechnic University · ITAzienda Ospedaliera Bolognini Seriate · ITFondazione Poliambulanza Istituto Ospedaliero · ITKU Leuven · BEOspedale Sant Antonio · ITUniversitätsklinikum Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the last few years, more attention has been given to the "non-calcemic" effect of vitamin D. Several observational studies and meta-analyses demonstrated an association between circulating levels of vitamin D and outcome of many common diseases, including endocrine diseases, chronic diseases, cancer progression, and autoimmune diseases. In particular, cells of the immune system (B cells, T cells, and antigen presenting cells), due to the expression of 1α-hydroxylase (CYP27B1), are able to synthesize the active metabolite of vitamin D, which shows immunomodulatory properties. Moreover, the expression of the vitamin D receptor (VDR) in these cells suggests a local action of vitamin D in the immune response. These findings are supported by the correlation between the polymorphisms of the VDR or the CYP27B1 gene and the pathogenesis of several autoimmune diseases. Currently, the optimal plasma 25-hydroxyvitamin D concentration that is necessary to prevent or treat autoimmune diseases is still under debate. However, experimental studies in humans have suggested beneficial effects of vitamin D supplementation in reducing the severity of disease activity. In this review, we summarize the evidence regarding the role of vitamin D in the pathogenesis of autoimmune endocrine diseases, including type 1 diabetes mellitus, Addison's disease, Hashimoto's thyroiditis, Graves' disease and autoimmune polyendocrine syndromes. Furthermore, we discuss the supplementation with vitamin D to prevent or treat autoimmune diseases.

Indexed as

25-Hydroxyvitamin D3 1-alpha-HydroxylaseAddison DiseaseAnimalsAutoimmune DiseasesDiabetes Mellitus, Type 1Endocrine System DiseasesGraves DiseaseHumansPolymorphism, GeneticReceptors, CalcitriolVitamin DVitamin D Deficiency25-Hydroxyvitamin D3 1-alpha-HydroxylaseCYP27B1 protein, humanReceptors, CalcitriolVDR protein, humanVitamin DAddison’s diseaseAutoimmune polyendocrine syndromesAutoimmunityEnvironmentGraves’ diseaseHashimoto’s thyroiditisLifestyleType 1 diabetes mellitusVitamin D

Identifiers

PMID28070798
OpenAlexW2570746747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.