ArticleClinical rheumatology2017
Serum 25-OH vitamin D levels in systemic sclerosis: analysis of 140 patients and review of the literature.
Article in Clinical rheumatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Dualities of the vitamin D in systemic sclerosis: a systematic literature review.Advances in rheumatology (London, England) · 2021Pooled it
- Role of Vitamin D in Systemic Sclerosis: A Systematic Literature Review.Journal of immunology research · 2021Pooled it
- Vitamin D levels in systemic sclerosis patients: a meta-analysis.Drug design, development and therapy · 2017Pooled it
- [Osteoporosis treatment in systemic sclerosis : Challenges and strategies in daily clinical practice].Zeitschrift fur Rheumatologie · 2026Review
- Vitamin D insufficiency and cardiovascular involvement in systemic sclerosis: Association with echocardiographic parameters and risk factors.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Vitamin D, immune microenvironment, and cervical lesions: mechanisms and therapeutic strategies from polyps to carcinoma.Frontiers in nutrition · 2025Review
- Serum vitamin D levels and vitamin D receptor gene ApaI and TaqI polymorphisms in patients with morphea: a case-control study.Archives of dermatological research · 2023Article
- Preventative Care in Scleroderma: What Is the Best Approach to Bone Health and Cancer Screening?Rheumatic diseases clinics of North America · 2023Review
- Vitamin D and Autoimmune Rheumatic Diseases.Biomolecules · 2023Review
- Vitamin D in Systemic Sclerosis: A Review.Nutrients · 2022Review
- Micronutrient Deficiencies in Systemic Sclerosis: A Scoping Review.Open access rheumatology : research and reviews · 2022Article
- Article
- Vitamin D and connective tissue diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Review
- Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies.International journal of molecular sciences · 2018Review
- Malnutrition and sarcopenia in a large cohort of patients with systemic sclerosis.Clinical rheumatology · 2018Article
- Relationship between vitamin D and chronic spontaneous urticaria: a systematic review.Clinical and translational allergy · 2018Article
- Vitamin D deficiency in systemic sclerosis: a possible role of subclinical liver fibrosis? Retrospective analysis from an Italian cohort.Clinical rheumatology · 2017Article
- Vitamin D deficiency is associated with digital ulcer but not with atherosclerosis or arterial stiffness in patients with systemic sclerosis: a pilot study.Clinical rheumatology · 2017Article
- Associations between Systemic Sclerosis and Thyroid Diseases.Frontiers in endocrinology · 2017Review
- Evaluation of Serum Vitamin D Levels in Patients with Systemic Sclerosis and Healthy Controls: Results of a Pilot Study.Indian dermatology online journalArticle
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypovitaminosis D is increasingly reported in autoimmune diseases. We investigated the 25-OH-vitamin D (25-OH-vitD) levels in systemic sclerosis (SSc) patients, in correlation with disease's features. We measured the 25-OH-vitD serum levels in 140 consecutive patients (F/M 126/15; mean age 61 ± 15.1 years), 91 without (group A) and 49 with (group B) 25-OH-cholecalciferol supplementation. Patients of group A invariably showed low 25-OH-vitD levels (9.8 ± 4.1 ng/ml vs. 26 ± 8.1 ng/ml of group B); in particular, 88/91 (97%) patients showed vitamin D deficiency (<20 ng/ml), with very low vitamin D levels (<10 ng/ml) in 40 (44%) subjects. Only 15/49 (30.6%) patients of group B reached normal levels of 25-OH-vitD (≥30 ng/ml), whereas vitamin D deficiency persisted in 12/49 (24.5%) individuals. Parathormone levels inversely correlated with 25-OH-vitD (r = -0.3, p < 0.0001). Of interest, hypovitaminosis D was statistically associated with autoimmune thyroiditis (p = 0.008), while calcinosis was more frequently observed in patients of group A (p = 0.057). Moreover, we found significantly higher percentage of serum anticentromere antibodies in group B patients with 25-OH-vitD level ≥30 ng/ml (8/15 vs. 6/34; p = 0.017). In literature, hypovitaminosis D is very frequent in SSc patients. An association with disease duration, calcinosis, or severity of pulmonary involvement was occasionally recognized. Hypovitaminosis D is very frequent in SSc and severe in a relevant percentage of patients; furthermore, less than one third of supplemented subjects reached normal levels of 25-OH-vitD. The evaluation of 25-OH-vitD levels should be included in the routine clinical work-up of SSc. The above findings expand previous observations and may stimulate further investigations.
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