ArticleActa diabetologica2017
Examining trends in prediabetes and its relationship with the metabolic syndrome in US adolescents, 1999-2014.
Article in Acta diabetologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04523363 (Metformin Versus Standard of Care Treatment in Pregnant Women With Prediabetes), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metformin Versus Standard of Care Treatment in Pregnant Women With Prediabetes: A Randomized Trial
Open the trial in the graphWho cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- The healthy Nordic diet for blood glucose control: a systematic review and meta-analysis of randomized controlled clinical trials.Acta diabetologica · 2020Pooled it
- The relationship between sarcopenic obesity and prediabetes in adolescents: Analysis of the national health and nutrition examination survey from 2011 to 2016.Journal of clinical & translational endocrinology · 2025Article
- Trends in Children's Dietary Inflammatory Index and association with prediabetes in U.S. adolescents.Nutrition & diabetes · 2024Article
- A Comprehensive Youth Diabetes Epidemiological Data Set and Web Portal: Resource Development and Case Studies.JMIR public health and surveillance · 2024Article
- U.S. Adolescent Rest-Activity patterns: insights from functional principal component analysis (NHANES 2011-2014).The international journal of behavioral nutrition and physical activity · 2023Article
- Youth-Onset Type 2 Diabetes: The Epidemiology of an Awakening Epidemic.Diabetes care · 2023Review
- Article
- Undiagnosed prediabetes in Mexican adolescents under poverty in contexts affected by collective violence: A clinical comparison among health services users and hidden population.Frontiers in nutrition · 2022Article
- The Impact of Obesity Assessed by Different Criteria on the Metabolic Parameters in Children and Adolescents in Georgia.Global pediatric health · 2022Article
- Trends and Risk Factors of Metabolic Syndrome among Korean Adolescents, 2007 to 2018.Diabetes & metabolism journal · 2021Article
- Predicting youth diabetes risk using NHANES data and machine learning.Scientific reports · 2021Article
- Clustering of cardio-metabolic risk factors and pre-diabetes among U.S. adolescents.Scientific reports · 2021Article
- Prediabetes in Adolescents: Prevalence, Management and Diabetes Prevention Strategies.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Review
- High prevalence of undiagnosed comorbidities among adolescents with obesity.Scientific reports · 2020Article
- Severity of the metabolic syndrome as a predictor of prediabetes and type 2 diabetes in first degree relatives of type 2 diabetic patients: A 15-year prospective cohort study.World journal of diabetes · 2020Article
- Prevalence of prediabetes and type 2 diabetes in children with obesity and increased transaminases in European German-speaking countries. Analysis of the APV initiative.Pediatric obesity · 2020Article
- The prevalence of undiagnosed Prediabetes/type 2 diabetes, prehypertension/hypertension and obesity among ethnic groups of adolescents in Western Canada.BMC pediatrics · 2020Article
- Review
- Childhood obesity in New Zealand.World journal of pediatrics : WJP · 2019Review
- Prediabetes: An emerging public health concern in adolescents.Endocrinology, diabetes & metabolism · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
aimsWe sought to investigate temporal trends in prediabetes prevalence among US adolescents using two definitions and evaluate relationships with obesity and a MetS-severity score.
methodsWe evaluated data from 5418 non-Hispanic white, non-Hispanic black, and Hispanic adolescents aged 12-19 participating in the National Health and Nutrition Examination Survey 1999-2014 with complete data regarding MetS and hemoglobin A1c (HbA1c). Prediabetes status was defined by American Diabetes Association (ADA) criteria: fasting glucose 100-125 mg/dL or HbA1c 5.7%-6.4%. MetS severity was assessed with a MetS-severity Z-score.
resultsPrevalence of prediabetes as defined by HbA1c abnormalities significantly increased from 1999-2014, while prevalence of prediabetes as defined by fasting glucose abnormalities showed no significant temporal trend. There were variations in these trends across different racial/ethnic groups. MetS Z-score was overall more strongly correlated with HbA1c, fasting insulin, and the homeostasis model of insulin resistance than was BMI Z-score. These correlations were true in each racial/ethnic group with the exception that in non-Hispanic white adolescents, in whom the MetS Z-score was not significantly correlated with HbA1c measurements.
conclusionWe found conflicting findings of temporal trends of US adolescent prediabetes prevalence based on the ADA's prediabetes criteria. The increasing prevalence of prediabetes by HbA1c assessment is concerning and raises the urgency for increased awareness and appropriate measures of prediabetes status among physicians and patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.