Evidence map›Paper›PMID 28070746›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2017

Boundary Cap Neural Crest Stem Cells Promote Survival of Mutant SOD1 Motor Neurons.

Tanya Aggarwal, Jan Hoeber, Patrik Ivert, Svitlana Vasylovska, Elena N Kozlova

Open access · hybridAbstract read
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Towards 3D Bioprinted Spinal Cord Organoids.International journal of molecular sciences · 2022
    Article
  5. Neural crest-like stem cells for tissue regeneration.Stem cells translational medicine · 2021
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tanya AggarwalDepartment of Neuroscience, Uppsala University Biomedical Center, Box 593, 75124, Uppsala, Sweden.
Jan HoeberDepartment of Neuroscience, Uppsala University Biomedical Center, Box 593, 75124, Uppsala, Sweden.
Patrik IvertDepartment of Neuroscience, Uppsala University Biomedical Center, Box 593, 75124, Uppsala, Sweden.
Svitlana VasylovskaDepartment of Neuroscience, Uppsala University Biomedical Center, Box 593, 75124, Uppsala, Sweden.
Elena N KozlovaDepartment of Neuroscience, Uppsala University Biomedical Center, Box 593, 75124, Uppsala, Sweden. elena.kozlova@neuro.uu.se.
Uppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ALS is a devastating disease resulting in degeneration of motor neurons (MNs) in the brain and spinal cord. The survival of MNs strongly depends on surrounding glial cells and neurotrophic support from muscles. We previously demonstrated that boundary cap neural crest stem cells (bNCSCs) can give rise to neurons and glial cells in vitro and in vivo and have multiple beneficial effects on co-cultured and co-implanted cells, including neural cells. In this paper, we investigate if bNCSCs may improve survival of MNs harboring a mutant form of human SOD1 (SOD1

Indexed as

Neural CrestNeural Stem CellsAmyotrophic Lateral SclerosisAnimalsCells, CulturedCell SurvivalHumansMiceMice, NudeMotor NeuronsMutationStem Cell TransplantationSuperoxide Dismutase-1SOD1 protein, humanSuperoxide Dismutase-1Amyotrophic lateral sclerosisNeurodegenerationNeurogliaOxidative stressTransplantation

Identifiers

PMID28070746
PMCPMC5509618
OpenAlexW2570874113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.