Evidence map›Paper›PMID 28070709›Full record

ArticleEndocrine2017

Influence of resveratrol on endoplasmic reticulum stress and expression of adipokines in adipose tissues/adipocytes induced by high-calorie diet or palmitic acid.

Li Chen, Ting Wang, Guanjun Chen, Nuojin Wang, Li Gui, Fang Dai, Zhaohui Fang, Qiu Zhang, Yunxia Lu

Abstract read
PubMed Publisher
In one paragraph

Article in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Resveratrol supplementation improves metabolic control in rats with induced hyperlipidemia and type 2 diabetes.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Li ChenClinical Laboratory, Anhui Provincial Hospital, Hefei, Anhui, 230001, China.
Ting WangEndocrinology Department, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China.
Guanjun ChenDepartment of Chemistry, Anhui Medical University, Hefei, Anhui, 230032, China.
Nuojin WangEndocrinology Department, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China.
Li GuiThe Comprehensive Laboratory, Anhui Medical University, Hefei, Anhui, 230032, China.
Fang DaiEndocrinology Department, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China.
Zhaohui FangDepartment of Endocrinology, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui, 230032, China.
Qiu ZhangEndocrinology Department, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China.
Yunxia LuThe Comprehensive Laboratory, Anhui Medical University, Hefei, Anhui, 230032, China. wwwdluyx@sina.com.ORCID http://orcid.org/0000-0002-8739-7789
Anhui Medical University · CNAnhui Provincial Hospital · CNAnhui University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to determine whether resveratrol treatment alleviates endoplasmic reticulum stress and changes the expression of adipokines in adipose tissues and cells.

methods8-week-old male C57BL/6 mice were fed a high-calorie diet (HCD group) or high-calorie diet supplemented with resveratrol (high-calorie diet  + resveratrol group) for 3 months. Insulin resistance, serum lipids and proinflammatory indices, the size and inflammatory cell infiltration in subcutaneous and visceral adipose tissues were analyzed. The gene expressions of endoplasmic reticulum stress, adipokines, and inflammatory cytokines were determined. The induced mature 3T3-L1 cells were pretreated with resveratrol and then palmitic acid, and the gene expressions of endoplasmic reticulum stress, adipokines, and inflammatory cytokines were determined.

resultsSubcutaneous and visceral adipose tissues in the high-calorie diet-fed mice exhibited adipocyte hypertrophy, inflammatory activation, and endoplasmic reticulum stress. Resveratrol alleviated high-calorie diet-induced insulin resistance and endoplasmic reticulum stress, increased expression of SIRT1, and reversed expression of adipokines in varying degrees in both subcutaneous and visceral adipose tissues. The effects of resveratrol on palmitic acid-treated adipocytes were similar to those shown in the tissues.

conclusionsResveratrol treatment obviously reversed adipocyte hypertrophy and insulin resistance by attenuating endoplasmic reticulum stress and inflammation, thus increasing the expression of SIRT1 and inverting the expression of adipokines in vivo and in vitro.

Indexed as

3T3-L1 CellsAdipocytesAdipokinesAdipose TissueAnimalsCell DifferentiationEndoplasmic Reticulum StressInsulin ResistanceLipidsMaleMicePalmitic AcidResveratrolStilbenesAdipokinesLipidsPalmitic AcidResveratrolStilbenes3T3L1Adipose tissuesEndoplasmic reticulum stressHigh-calorie dietPalmitic acidResveratrol

Identifiers

PMID28070709
OpenAlexW2569624086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.