ArticlePsychopharmacology2017
A pooled analysis of on-the-road highway driving studies in actual traffic measuring standard deviation of lateral position (i.e., "weaving") while driving at a blood alcohol concentration of 0.5 g/L.
Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- High-dose L-theanine-caffeine combination improves neurobehavioural and neurophysiological measures of selective attention in acutely sleep-deprived young adults: a double-blind, placebo-controlled crossover study.The British journal of nutrition · 2025Trial
- Residual next-day effects of alprazolam on psychomotor performance and simulated driving in healthy normal adults.Experimental and clinical psychopharmacology · 2025Trial
- Preliminary study of the interactive effects of THC and ethanol on self-reported ability and simulated driving, subjective effects, and cardiovascular responses.Psychopharmacology · 2023Trial
- Effects of solriamfetol on on-the-road driving in participants with narcolepsy: A randomised crossover trial.Human psychopharmacology · 2023Trial
- Fit for purpose of on-the-road driving and simulated driving: A randomised crossover study using the effect of sleep deprivation.PloS one · 2023Trial
- Effects of solriamfetol on on-the-road driving performance in participants with excessive daytime sleepiness associated with obstructive sleep apnoea.Human psychopharmacology · 2022Trial
- Validity and reliability of a driving simulator for evaluating the influence of medicinal drugs on driving performance.Psychopharmacology · 2021Trial
- Trial
- Trial
- A clinical trial on the acute effects of methadone and buprenorphine on actual driving and cognitive function of healthy volunteers.British journal of clinical pharmacology · 2019Trial
- Development of the DADSS* Breath Alcohol Sensor System for Automobiles: Technical Design and Human Participant Testing.Sensors (Basel, Switzerland) · 2026Article
- Evaluating and Determining the Effects of Psychotropic Drugs on Motor Vehicle Driving Performance: Key Considerations of the Japanese Guideline and Criteria for Clinical Implementation of Evidence.Neuropsychopharmacology reports · 2026Review
- Recent Advances in the Science of Cannabis-Impaired Driving.Current addiction reports · 2026Review
- Cannabis and Driving in Older Adults.JAMA network open · 2024Article
- Comparing objective wakefulness and vigilance tests to on-the-road driving performance in narcolepsy and idiopathic hypersomnia.Journal of sleep research · 2022Article
- An explorative approach to understanding individual differences in driving performance and neurocognition in long-term benzodiazepine users.Human psychopharmacology · 2021Article
- Driving performance and neurocognitive skills of long-term users of sedating antidepressants.Human psychopharmacology · 2021Article
- Driving performance and neurocognitive skills of long-term users of benzodiazepine anxiolytics and hypnotics.Human psychopharmacology · 2019Article
- Protocol for the development and validation of a driving simulator for evaluating the influence of drugs on driving performance.Medicine · 2019Article
- Single- and dual-task performance during on-the-road driving at a low and moderate dose of alcohol: A comparison between young novice and more experienced drivers.Human psychopharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe on-the-road highway driving test is generally regarded as a gold standard for assessing drug-induced driving impairment. The primary outcome measure is the standard deviation of lateral position (SDLP), a measure of road tracking error or "weaving". The test has been calibrated for incremental doses of alcohol almost 30 years ago in order to define the impact of drug-induced impairment in terms of blood alcohol concentration (BAC) equivalents. Drug-induced changes in SDLP exceeding 2.4 cm have been evaluated as clinically relevant ever since. The present analysis was conducted to assess the robustness of the alcohol effect in a range of on-the-road driving studies which have been conducted since the initial alcohol calibration study.
methodsThe present study pooled data of 182 participants from nine placebo-controlled crossover studies who performed the highway driving test, while their BAC was at or just below the legal limit for drivers (i.e., 0.5 g/L).
resultsOverall, mean SDLP increased with 2.5 cm (95% CI 2.0-2.9 cm). Equivalence testing showed that the clinical relevance criterion value of 2.4 cm fell well within the 95% CI in each individual study. Gender did not affect alcohol-induced changes in SDLP. DISCUSSION: These results demonstrate the robustness and validity of the clinical relevance criterion for SDLP as measured during on-the-road driving.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.