ArticleBioMed research international2016
Multiple Genetic Associations with Irish Wolfhound Dilated Cardiomyopathy.
Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Risk factors for atrial fibrillation in dogs with dilated cardiomyopathy.Frontiers in veterinary science · 2023Article
- Genetic Basis of Dilated Cardiomyopathy in Dogs and Its Potential as a Bidirectional Model.Animals : an open access journal from MDPI · 2022Review
- Effect of diet change in healthy dogs with subclinical cardiac biomarker or echocardiographic abnormalities.Journal of veterinary internal medicine · 2022Article
- Effect of type of diet on blood and plasma taurine concentrations, cardiac biomarkers, and echocardiograms in 4 dog breeds.Journal of veterinary internal medicine · 2021Article
- Retrospective study of dilated cardiomyopathy in dogs.Journal of veterinary internal medicine · 2021Article
- Article
- Review of canine dilated cardiomyopathy in the wake of diet-associated concerns.Journal of animal science · 2020Review
- Echocardiographic and electrocardiographic evaluation of North American Irish Wolfhounds.Journal of veterinary internal medicine · 2020Article
- Article
- Inherited cardiomyopathies in veterinary medicine.Pflugers Archiv : European journal of physiology · 2019Review
- Pedigree analysis of atrial fibrillation in Irish wolfhounds supports a high heritability with a dominant mode of inheritance.Canine genetics and epidemiology · 2019Article
- Multiple Species Comparison of Cardiac Troponin T and Dystrophin: Unravelling the DNA behind Dilated Cardiomyopathy.Journal of cardiovascular development and disease · 2017Review
- Genomic Insights into Cardiomyopathies: A Comparative Cross-Species Review.Veterinary sciences · 2017Review
- Echocardiographic and electrocardiographic findings in Irish Wolfhounds eating high-pulse or low-pulse diets.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac disease is a leading cause of morbidity and mortality in dogs and humans, with dilated cardiomyopathy being a large contributor to this. The Irish Wolfhound (IWH) is one of the most commonly affected breeds and one of the few breeds with genetic loci associated with the disease. Mutations in more than 50 genes are associated with human dilated cardiomyopathy (DCM), yet very few are also associated with canine DCM. Furthermore, none of the identified canine loci explain many cases of the disease and previous work has indicated that genotypes at multiple loci may act together to influence disease development. In this study, loci previously associated with DCM in IWH were tested for associations in a new cohort both individually and in combination. We have identified loci significantly associated with the disease individually, but no genotypes individually or in pairs conferred a significantly greater risk of developing DCM than the population risk. However combining three loci together did result in the identification of a genotype which conferred a greater risk of disease than the overall population risk. This study suggests multiple rather than individual genetic factors, cooperating to influence DCM risk in IWH.
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