ReviewBioMed research international2016
Sunlight Effects on Immune System: Is There Something Else in addition to UV-Induced Immunosuppression?
Review in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 95 citations in OpenAlex.
- UV-induced immune modulation in the lung niche slows cancer progression.Scientific reports · 2026Article
- Skin-directed Solius UVB light therapy increases vitamin D levels and alters intestinal microbiome and metabolome homeostasis.Frontiers in microbiology · 2026Article
- Anatomical Locations of Keratinocyte Carcinomas Among United States Veterans Affairs Healthcare System Patients in Minnesota: A Cross-Sectional Study.Experimental dermatology · 2025Article
- Therapeutic Sunbathing in Yoga and Naturopathy Hospitals: Establishing National Standards through the Delphi Methodology.Journal of lifestyle medicine · 2025Article
- Endocrine and Reproductive Health Considerations of Sunscreen UV Filters: Insights from a Comprehensive Review 2014-2024.Current environmental health reports · 2025Review
- Carvedilol Prevents UV-Induced Immunosuppression and Skin Carcinogenesis through a Mechanism Independent of β-Blockade.JID innovations : skin science from molecules to population health · 2025Article
- Article
- Examination of the biological effects of sunlight on the skin: a review.Journal of lasers in medical sciences · 2025Review
- Activation of CDKN2A and Up-regulation of PETN Are Key Features of Sunscreen Usage Versus Light Irradiation.Journal of lasers in medical sciences · 2025Article
- Comparison of Biomarkers Playing a Role in Pterygium Development in Pterygium and Recurrent Pterygium Tissues.Diagnostics (Basel, Switzerland) · 2024Article
- Visible light accelerates skin wound healing and alleviates scar formation in mice by adjusting STAT3 signaling.Communications biology · 2024Article
- Crosslinking of Ly6a metabolically reprograms CD8 T cells for cancer immunotherapy.Nature communications · 2024Article
- Microparticles Made with Silk Proteins for Melanoma Adjuvant Therapy.Gels (Basel, Switzerland) · 2024Article
- Common skin cancers and their association with other non-cutaneous primary malignancies: a review of the literature.Medical oncology (Northwood, London, England) · 2024Review
- Review
- The "Watch Sign" - Another Observation in the Course of Male Frontal Fibrosing Alopecia.Dermatology practical & conceptual · 2024Article
- Association of air pollution and weather conditions during infection course with COVID-19 case fatality rate in the United Kingdom.Scientific reports · 2024Article
- Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary-lung axis.Nature communications · 2023Article
- Influence of Different Light Spectra on Melatonin Synthesis by the Pineal Gland and Influence on the Immune System in Chickens.Animals : an open access journal from MDPI · 2023Review
- Solid Lipid Nanoparticles Hydroquinone-Based for the Treatment of Melanoma: Efficacy and Safety Studies.Pharmaceutics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sunlight, composed of different types of radiation, including ultraviolet wavelengths, is an essential source of light and warmth for life on earth but has strong negative effects on human health, such as promoting the malignant transformation of skin cells and suppressing the ability of the human immune system to efficiently detect and attack malignant cells. UV-induced immunosuppression has been extensively studied since it was first described by Dr. Kripke and Dr. Fisher in the late 1970s. However, skin exposure to sunlight has not only this and other unfavorable effects, for example, mutagenesis and carcinogenesis, but also a positive one: the induction of Vitamin D synthesis, which performs several roles within the immune system in addition to favoring bone homeostasis. The impact of low levels of UV exposure on the immune system has not been fully reported yet, but it bears interesting differences with the suppressive effect of high levels of UV radiation, as shown by some recent studies. The aim of this article is to put some ideas in perspective and pose some questions within the field of photoimmunology based on established and new information, which may lead to new experimental approaches and, eventually, to a better understanding of the effects of sunlight on the human immune system.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.