Evidence map›Paper›PMID 28070463›Full record

ArticlePeerJ2017

Impact of birth weight and postnatal diet on the gut microbiota of young adult guinea pigs.

Kait Al, Ousseynou Sarr, Kristyn Dunlop, Gregory B Gloor, Gregor Reid, Jeremy Burton, Timothy R H Regnault

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. PlacentaAmerican journal of physiology. Endocrinology and metabolism · 2025
    Article
  3. Heliyon · 2024
    Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kait AlDepartment of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada; Canadian Centre for Human Microbiome and Probiotic Research, London, Ontario, Canada; Lawson Health Research Institute, London, Ontario, Canada.
Ousseynou SarrLawson Health Research Institute, London, Ontario, Canada; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada; Department of Obstetrics and Gynaecology, University of Western Ontario, London, Ontario, Canada; Children's Health Research Institute, London, Ontario, Canada.
Kristyn DunlopDepartment of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada; Department of Obstetrics and Gynaecology, University of Western Ontario, London, Ontario, Canada.
Gregory B GloorDepartment of Biochemistry, University of Western Ontario , London , Ontario , Canada.
Gregor ReidDepartment of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada; Canadian Centre for Human Microbiome and Probiotic Research, London, Ontario, Canada; Lawson Health Research Institute, London, Ontario, Canada; Department of Surgery, Division of Urology, University of Western Ontario, London, Ontario, Canada.
Jeremy BurtonDepartment of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada; Canadian Centre for Human Microbiome and Probiotic Research, London, Ontario, Canada; Lawson Health Research Institute, London, Ontario, Canada; Department of Surgery, Division of Urology, University of Western Ontario, London, Ontario, Canada.
Timothy R H RegnaultLawson Health Research Institute, London, Ontario, Canada; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada; Department of Obstetrics and Gynaecology, University of Western Ontario, London, Ontario, Canada; Children's Health Research Institute, London, Ontario, Canada.
Western University · CALawson Health Research Institute · CAChildren’s Health Research Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe gastrointestinal tract (GIT) microbiota is essential to metabolic health, and the prevalence of the Western diet (WD) high in fat and sugar is increasing, with evidence highlighting a negative interaction between the GIT and WD, resulting in liver dysfunction. Additionally, an adverse

methodsThe fecal microbiota of normal birth weight (NBW) and LBW young guinea pig offspring, weaned onto either a control diet (CD) or WD was determined with 16S rRNA gene next generation sequencing at young adulthood following the early rapid growth phase after weaning. A liver blood chemistry profile was also performed.

resultsThe life-long consumption of WD following weaning into young adulthood resulted in increased total cholesterol, triglycerides and alanine aminotransferase levels in association with an altered GIT microbiota when compared to offspring consuming CD. Neither birth weight nor sex were associated with any significant changes in microbiota alpha diversity, by measuring the Shannon's diversity index. One hundred forty-eight operational taxonomic units were statistically distinct between the diet groups, independent of birth weight. In the WD group, significant decreases were detected in DISCUSSION: These results describe the GIT microbiota in a guinea pig model of LBW and WD associated metabolic syndrome and highlight several WD specific GIT alterations associated with human metabolic disease.

Indexed as

Microbiome

Identifiers

PMID28070463
PMCPMC5214890
OpenAlexW2565222406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.